Biomedical research is growing at such an exponential pace that scientists, researchers, and practitioners are no more able to cope with the amount of published literature in domain. The knowledge presented needs be systematized a way claims hypotheses can easily found, accessed, validated. Knowledge graphs provide framework for semantic representation from literature. However, order build grap...

the energy of a graph is equal to the sum of the absolute values of its eigenvalues. two graphs of the same order are said to be equienergetic if their energies are equal. we point out the following two open problems for equienergetic graphs. (1) although it is known that there are numerous pairs of equienergetic, non-cospectral trees, it is not known how to systematically construct any such pa...

Quantum-chemical fragmentation methods offer an efficient approach for the treatment of large proteins, in particular if local target quantities such as protein–ligand interaction energies, enzymatic reaction or spectroscopic properties embedded chromophores are sought. However, accuracy that is achievable intricately depends on how protein partitioned into smaller fragments. While commonly emp...