نتایج جستجو برای: grn reverse engineering models
تعداد نتایج: 1233163 فیلتر نتایج به سال:
Progranulin (PGRN) is a secreted protein expressed ubiquitously throughout the body, including the brain, where it localizes in neurons and is activated microglia. Loss-of-function mutations in the GRN gene are an important cause of familial frontotemporal lobar degeneration (FTLD). PGRN has a neurotrophic and anti-inflammatory activity, and it is neuroprotective in several injury conditions, s...
INTRODUCTION ...................................................................................210 I. THE INTELLECTUAL PROPERTY CONTEXT OF REVERSE ENGINEERING..............................................................................212 A. Intellectual Property Law and Reverse Engineering ............212 B. No Coherent Treatment of Reverse Engineering.................215 II. REVERSE ENGINEE...
Granulin A (GRN A), a peptide with a molecular 6 kDa, is derived from proteolysis of progranulin (PGRN). Previous study in our laboratory has shown that GRN A is able to inhibit cancer cell growth significantly. In the present study, we confirmed that GRN A can bind to α-enolase (ENO1) specifically as analyzed using Pull-down/MS approaches. The interaction of GRN A with ENO1 was further confirm...
Complex ecosystems, from food webs to our gut microbiota, are essential to human life. Understanding the dynamics of those ecosystems can help us better maintain or control them. Yet, reverse-engineering complex ecosystems (i.e., extracting their dynamic models) directly from measured temporal data has not been very successful so far. Here we propose to close this gap via symbolic regression. W...
Fab-less business model in semiconductor industry has led to serious concerns about trustworthy hardware. In untrusted foundries and manufacturing companies, submitted layout may be analyzed and reverse engineered to steal the information of a design or insert malicious Trojans. Understanding the netlist topology is the ultimate goal of the reverse engineering process. In this paper, we propose...
There is a wide range of formats and meta-models to represent the information extracted by reverse engineering tools. Currently UML tools with reverse engineering capabilities are not truly interoperable due to differences in the interchange format and cannot extract complete and integrated models. The forthcoming UML 2.0 standard includes a complete meta-model and a well defined interchange fo...
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