Bechara C, Wang X, Chai H, Lin PH, Yao Q, Chen C. Growthrelated oncogeneinduces endothelial dysfunction through oxidative stress and downregulation of eNOS in porcine coronary arteries. Am J Physiol Heart Circ Physiol 293: H3088–H3095, 2007. First published September 14, 2007; doi:10.1152/ajpheart.00473.2007.—Growth-related oncogene(GRO) is a member of the CXC chemokine family, which is involve...

An early response to cigarette smoke is an influx of leukocytes into the lung. Alveolar epithelial type II (ATII) cells may contribute by releasing chemokines in response to cigarette smoke and neutrophil elastase (NE). Human ATII cells were purified from normal regions of lungs resected for carcinoma (n = 14). In vitro, these cells exhibited ATII cell characteristics: lamellar bodies, apical m...

The purpose of this study was to characterize the pattern of cytokine gene expression by human corneal epithelial cells (HCEC) in response to interleukin-1 (IL-1). Primary cultured HCEC (P-HCEC) or SV40 transformed HCEC (SV40-HCEC) were treated for 6 hr with serum-free growth-media alone or with recombinant human IL-1beta or IL-1alpha (10 ng ml(-1)). 33P labeled cDNA was generated from total RN...

Chemotherapy-induced peripheral neuropathy (CIPN) is a type of neuropathic pain that represents a frequent and serious consequence of chemotherapy agents. Over the last years, significant progress has been achieved in elucidating the underlying pathogenesis of CIPN. The interference of taxanes with microtubule has been proposed as a mechanism that leads to altered axonal transport and to perman...

A model for GROJ1655-40 is described in which the hard X/~-ray behavior, and long delay between the X/~ and radio outbursts, are explained by processes which occur when the accretion rate approaches and exceeds the Eddington limit. The principal feature of the model is a dense, optically thick, super-Eddington wind ejected from the center of the accretion disk. The wind is responsible for deter...

The basal transcription of the CXC chemokine, melanocyte growth stimulatory activity (MGSA)/growth-regulated protein (GRO)-a, is upregulated in Hs294T melanoma cells compared with the normal retinal pigment epithelial (RPE) cells. Previous studies characterized a cytokineinducible, functional nuclear factor (NF) -kB consensus element in the immediate 5* regulatory region of the MGSA/GRO-a gene ...