Generalized tonic-clonic seizure (GTCS) is the commonest seizure type associated with sudden unexpected death in epilepsy (SUDEP). This study examined the semiological and electroencephalographic differences (EEG) in the GTCSs of adults as compared with those of children. The rationale lies on epidemiological observations that have noted a tenfold higher incidence of SUDEP in adults. We analyze...

BACKGROUND Epileptic seizures, predominantly or exclusively during sleep had been the focus of attention for many electroencephalographers. Though few epileptic syndromes are associated with sleep seizures (SS) its frequencies in Indian patients is still unknown. AIM To find out the patterns of epilepsies in patients having SS and compare them with patients having wake seizures (WS). SETTIN...

Meningioma is an apparently benign brain tumour originating from the arachnoid cells lining the meninges or the choroid plexuses. Approximately 1% to 4% of primary intracranial tumours in the paediatric group is meningioma and is increasing in incidence with age. Commonly there is variation in site of involvement, symptoms, histological picture and prognosis in relation to adult counterparts. I...

Epilepsy is the most prevalent chronic neurological disorder, and its pathological mechanism indicates that an imbalance between excitatory and inhibitory neurotransmission leads to neuronal hyperexcitability. Previous studies have suggested that dl-3n-butylphthalide (NBP) regulates the excitatory neurotransmitter glutamate in the brains of epileptic mice, however, the mechanisms are unknown. W...

2005 2 Animum rege, qui nisi paret, imperat. distribution and neuronal localization of c-fos protein in the rat hippocampus following 4-aminopyridine seizures.competitive NMDA receptor antagonists moderate seizure-induced c-fos expression in the rat cerebral cortex. Z.: Alterations of seizure-induced c-fos expression in the rat cerebral cortex following dexamethasone treatment. (submitted) V.fo...

PURPOSE Evaluation of the efficacy and side effects profile of Clobazam in a 24-week open-labelled trial involving 26 cases of drug naïve adult patients with epilepsy. METHODS The study was an open labelled unicentre trial in which only drug naïve cases with epilepsy were included. A total of 26 cases were recruited. One case was dropped because he did not complete the desired follow up. Seiz...

INTRODUCTION Lafora body disease (LBD) is a rare autosomal recessive disorder characterized by progression to inexorable dementia and frequent occipital seizures, in addition to myoclonus and generalized tonic-clonic seizures (GTCSs). It belongs to the group of progressive myoclonus epilepsies (PMEs), rare inherited neurodegenerative diseases with great clinical and genetic differences, as well...

BACKGROUND Sudden unexpected death in epilepsy (SUDEP) is rare in well-controlled epilepsy. However, SUDEP is a common cause of death in drug-resistant epilepsy. Over the last 30 years, multiple cohort and population studies have identified clinical risk factors associated with an increased risk for SUDEP. OBJECTIVE To identify and rank the leading SUDEP risk factors from major cohort and pop...

Abstract Background Post-traumatic epilepsy is defined as the onset of at least one seizure beyond first week following a traumatic brain injury (TBI). High prevalence TBI in our setting may contribute to burden adult population. This retrospective review medical records patients admitted from January 1st, 2010 December 31st, 2019) Douala General Hospital. We included aged ≥ 18 years with after...

OBJECTIVE In the present work, the effects of different fractions of Coriandrum sativum (C. sativum), on pentylenetetrazole (PTZ)-induced seizures and brain tissues oxidative damage were investigated in rats. MATERIALS AND METHODS The rats were divided into the following groups: (1) vehicle, (2) PTZ (90 mg/kg), (3) water fraction (WF) of C. sativum (25 and 100 mg/kg), (4) n-butanol fraction (...