Cooper, P. J., M.-L. Ward, P. J. Hanley, G. R. Denyer, and D. S. Loiselle. Metabolic consequences of a species difference in Gibbs free energy of Na/Ca exchange: rat versus guinea pig. Am J Physiol Regulatory Integrative Comp Physiol 280: R1221–R1229, 2001.—The Gibbs free energy of the sarcolemmal Na/Ca exchanger (DGNa/Ca) determines its net Ca flux. We tested the hypothesis that a difference o...

BACKGROUND The photo-thermal effect has been hypothesised to be one of the most possible biophysical mechanisms for laser-cochlea stimulation. However, there is a lack of studies to date for direct assessing laser heating in humans due to the large body of evidence required to demonstrate safety and efficacy. Instead, the majority focus on animals like the guinea pig, from which a number of val...

Prostaglandin D2 (PGD2) causes cough and levels are increased in asthma suggesting that it may contribute to symptoms. Although the prostaglandin D2 receptor 2 (DP2) is a target for numerous drug discovery programmes little is known about the actions of PGD2 on sensory nerves and cough. We used human and guinea pig bioassays, in vivo electrophysiology and a guinea pig conscious cough model to a...

The ovalbumin (OVA)-sensitized guinea pig is often used as an animal model of asthma and airway hyperreactivity. A characteristic lesion of asthma is excessive production of mucin in the airways. Mechanistic studies of this lesion in guinea pigs have been limited due to lack of mucin gene probes for this species. The aim of the present study was to clone the cDNAs encoding two major airway muci...

Transient receptor potential vanilloid 1 (TRPV1) plays an integral role in modulating the cough reflex, and it is an attractive antitussive drug target. The purpose of this study was to characterize a TRPV1 antagonist, 4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), against the guinea pig TRPV1 receptor in vitro followed by a...

Andropogon muricatus Nash., has been used in the traditional medicine as an antispasmodic and in palpitation and this study was aimed to provide scientific basis for its use in gastrointestinal and cardiovascular disorders. Apporaximatly 2 cm long segments of rabbit jejunum and 2-3 mm wide aortic rings and strips of guinea-pig atria were incubated in normal Tyrod’s and Krab’s solutions at 37°C ...

Strains of Bacteroides gingivalis were compared for the presence of properties associated with pathogenicity. Some strains were infectious in pure culture in an in vivo model (guinea pig), and all but one of these were more collagenolytic than those which failed to cause lesions in guinea pigs. However, other factors seem to be necessary for the induction of an infection in this animal model.

In human cytomegalovirus (HCMV), tropism to epithelial and endothelial cells is dependent upon a pentameric complex (PC). Given the structure of the placenta, the PC is potentially an important neutralizing antibody target antigen against congenital infection. The guinea pig is the only small animal model for congenital CMV. Guinea pig cytomegalovirus (GPCMV) potentially encodes a UL128-131 HCM...

Feto-placental infections represent a major cause of pregnancy complications, and yet the underlying molecular and cellular mechanisms of vertical transmission are poorly understood. Listeria monocytogenes, a facultative intracellular pathogen, is one of a group of pathogens that are known to cause feto-placental infections in humans and other mammals. The purpose of this study was to evaluate ...

In vitro complement-mediated lysis of heavily sensitized sheep erythrocytes by C4-deficient (C4D) guinea pig and C2-deficient (C2D) human sera was demonstrated some years ago. It was postulated that these "complement-bypass" pathways resulted from activation of C1 and components of the alternative pathway. We used normal, C2D, and C4D guinea pigs in a Forssman shock model to test the in vivo re...