Comparative analysis between Caenorhabditis elegans and other nematode species offers a powerful approach to study gene function. C. elegans also has great potential as a surrogate expression system to study the function of genes from parasitic nematode species where transgenic methodologies are unavailable. However there is little information on the extent to which the biology of C. elegans is...

background: cross antigenicity is the major problem in developing a reliable tool for immunodiagnosis and immunoprophylaxis of parasitic diseases. mixed infection due to different types of gastrointestinal parasites is more common than single species infection under field condition. methods: the present study was undertaken to detect antigenic cross-reactivity among haemonchus contortus, oesoph...

Chemotherapy remains the foremost available tool for the control of nematode parasites. However, the substantial use of anthelmintics, combined with a scarcity of new anthelmintic classes, has led to a gradual increase in the resistance of nematode parasites to these compounds. Multi-Drug Resistance (MDR) in economically important livestock nematodes, such as Haemonchus contortus enables the pa...

In India, small ruminants contribute in providing economic security to small, landless and marginal farmers. Parasitic diseases are important cause of production losses in small ruminants the world over. Of these, gastrointestinal (GI) nematodosis is a common parasitic infection of small ruminants in India including sub-Himalyan region of northern India (Yadav et al., 2009). It is caused by mix...

A genetically diverse population of Haemonchus contortus was serially passaged through Merino hosts bred for either increased or decreased resistance to the parasite. After 30 parasite generations, the resulting nematode sub-populations were compared with each other and with the foundation population, by infecting lines of the selected sheep and measuring the resulting faecal egg counts (FECs) ...

BACKGROUND Cross antigenicity is the major problem in developing a reliable tool for immunodiagnosis and immunoprophylaxis of parasitic diseases. Mixed infection due to different types of gastrointestinal parasites is more common than single species infection under field condition. METHODS The present study was undertaken to detect antigenic cross-reactivity among Haemonchus contortus, Oesoph...

Anthelmintic resistance in parasitic nematodes of livestock is a chronic problem in many parts of the world. Benzimidazoles are effective, broad-spectrum anthelmintics that bind to and selectively depolymerise microtubules. Resistance to the benzimidazoles, however, developed quickly and is caused by genetic changes in genes encoding beta-tubulins, subunits of microtubules. In Haemonchus contor...

Angiostrongylus cantonensis is a bursate nematode parasite that causes eosinophilic meningitis (or meningoencephalitis) in humans in many parts of the world. The genomic data from A. cantonensis will form a useful resource for comparative genomic and chemogenomic studies to aid the development of diagnostics and therapeutics. We have sequenced, assembled and annotated the genome of A. cantonens...