Adoptive T-cell therapy with anti-CD19 chimeric antigen receptor (CAR)–expressing T cells is a new approach for treating advanced B-cell malignancies. To evaluate anti-CD19–CAR-transduced T cells in a murine model of adoptive T-cell therapy, we developed a CAR that specifically recognized murine CD19. We used T cells that were retrovirally transduced with this CAR to treat mice bearing a syngen...

Car-sharing systems have become a promising research direction due to the development of the Internet. Previous research mainly focus on how to pick more passengers up, which ignores whether the real income of car-drivers is increasing. In this paper, we exploit a model for car-sharing system named “MCSS”, which can make precise prediction on whether a passenger should be picked up while in an ...

This paper uses a panel of Swedish counties over the years 1988-99 to study the effects of unemployment on property crime rates. The period under study is characterized by great turbulence in the labor market – the variation in the unemployment rates is unprecedented in the second half of the century. The data hence provides a unique opportunity to investigate unemployment effects. According to...

This research effort analyzes the Wiedemann car-following model using car-following periods that occur at different speeds. The Wiedemann car-following model uses thresholds to define the different regimes in car following. Some of these thresholds use a speed parameter, but others rely solely upon the difference in speed between the subject vehicle and the lead vehicle. The results show that t...

The archaeon Sulfolobus solfataricus uses a catabolite repression-like system to control production of several glycoside hydrolases. To better understand this regulatory system, studies of the regulation of expression of the beta-glycosidase gene (lacS) were conducted. Expression of lacS varies in response to medium composition and to mutations at an unlinked gene called car. Despite gene overl...

Cars are ubiquitous and offer large and often highly visible surfaces that can be used as advertising space. Until now, advertising in this domain has focused on commercial vehicles, and advertisements have been painted on and were therefore static, with the exception of car-mounted displays that offer dynamic content. With new display technologies, we expect static displays or uniformly-painte...

A numerical model based on Lagrange-D’Alembert principle is proposed for car-to-car end impact in this paper. In the numerical model, the friction forces are treated by using local linearization model when solving the differential equations. A computer program has been developed for the numerical model based on Runge-Kutta fourth-order method. The results are compared with the Multibody Dynamic...

This paper deals with two modeling approaches to car driving. The first one is a system theoretic approach to describe adaptive human driving behavior. The second approach utilizes neural networks. As an illustrative example the overtaking task is considered and modeled in system theoretic terms. Model results are used to teach a neural network. The results show that a neural network is able to...

In this paper an H∞ controller is designed for a hydraulically actuated active suspension system of a half-modeled vehicle in a cascade feedback structure. Using the proposed structure the nonlinear behavior of actuator is reduced significantly. In the controller synthesis, a proportional controller is used in the inner loop, and a robust H∞ controller forms the outer loop. Two H∞ controllers a...

A nine-and-a-half-year-old dog was referred for investigation of bradycardia after being hit by a car. Electrocardiography revealed a third degree atrioventricular (AV) block. The dog died during a syncopal attack. Post mortem examination revealed an atrial septal tear with haemorrhage and myocardial degeneration affecting the AV bundle.