the characteristics associated with hepatocytes. They have glucose 6-phosphatase activity, secrete serum globulin, and, in confluent monolayers, show tight cell junctions and intercellular canaliculi resembling bile canaliculi. On the other hand, the cells have low levels of inducible tyrosine aminotransferase, no detectable 6-aminolevulinic acid synthetase and aryl hydrocarbon hydroxylase acti...

The successful heterologous transplantation of several human tumors, including a breast carcinoma, a carcinoma of the colon, a melanotic sarcoma, and a fibrosarcoma, has been reported. Histologically, the appearance of the transplants of the carcinomata differed from that of the spontaneous tumors, but the directly observed growth of the transplanted fragments together with the presence of inva...

We reported a case of sporadic multiple endocrine neoplasia type 1, with multiple insulinoma, parathyroid adenoma, and pituitary tumor. Measurement of hormone contents and immunohistochemical studies of the pancreatic tumors showed that the tumors contained insulin, glucagon, somatostatin, and pancreatic polypeptide. Furthermore, the concentrations of these hormones were different in each tumor...

introduction: photodynamic therapy is a noninvasive therapeutic method for tumors with a maximum depth of 5 mm. on the other hand, most photosensitizers are also susceptible to ultrasound waves (the basis of sonodynamic therapy). therefore, it is expected that a combination of the two therapeutic methods will increase effectiveness of photodynamic therapies for lower doses of sensitizer and cur...

Malignant tumors of pediatric hand are very rare. This case report describes an epithelioid sarcoma at the finger of an 11 year old girl and discusses general treatment options in this rare patient population.

Germ cell tumors account for less than 3% of all ovarian cancers. These tumors generally appear in childhood or in those under 30 years of age. Immature ovarian teratoma is the third most frequent germ cell tumor after dysgerminoma and endodermal sinus tumors. These tumors should be distinguished from mature teratomas. Discrimination of malignant and benign tumors depends on the presence of the...

mice were used. Autografts of either of these tumors grew better than isografts into normal mice. Attempts to transfer this conditioned status from primary hosts bearing MCA tumors to syngeneic recipients were unsuccessful. Neither with lymphoid cells nor with serum could we induce such state in recipient mice in which latency and growth of primary and transplanted, MCA-induced tumors was measu...

Inhalation of asbestos fibers is associated with high incidence of lung cancers and pleural or peritoneal mesotheliomas in humans. All of these lesions were successfully reproduced in animal experiment, and it was shown that asbestos neoplasm may occur with or without accompanying asbestosis. Incidence of tumors from crocidolite was nearly three times as high as from chrysotile or amosite. It i...

p53, a transformation-related cellular-encoded protein, was found to accumulate at high concentration in transformed cell lines. The results presented here show that p53 biosynthesis is also increased in most induced and spontaneous mouse tumors. Judged by the identity in antigenic determinants (estimated by binding to monoclonal antibodies), size, and partial peptide mapping, I conclude that t...