Thalassemia is defined as a condition in which reduced rate of synthesis of one or more of the globin chains leads to defective haemoglobin production. Of the two major types, in alphathalassemia, occhain synthesis is absent or diminished and in beta-thalassemia, B-chain synthesis is absent or diminished. In B-thalassemia, anaemia occurs due to reduced B globulin, which in turn reduces HbA resu...

Glycated haemoglobin (HbA1c) measured by high performance liquid chromatography (HPLC) in a 20 year old female with insulin dependent diabetes mellitus was consistently within the normal range although her daily blood glucose values were > 11.1 mmol/l. HbA1c measured by immunoagglutination and fructosamine was elevated and correlated with the patient's blood glucose values. The HPLC chromatogra...

This study investigated the prevalence of iron-deficiency anaemia, glucose-6-phosphate dehydrogenase (G6PD) deficiency and β-thalassaemia trait among Arab migrating nomad children in southern Islamic Republic of Iran. Blood samples were analysed from 134 schoolchildren aged < 18 years (51 males, 83 females). Low serum ferritin (< 12 ng/dL) was present in 17.9% of children (21.7% in females and ...

The role of the laboratory in the diagnosis of thalassemia and hemoglobinopathies is crucial. The objective of our study was to compare two common methods used in hemoglobinopathy and thalassemia investigation. Hemoglobin electrophoresis and HPLC (high performance liquid chromatography) were used to investigate patients suspected with thalassemia. A total of 301 adult and child blood samples we...

Therefore, it was somewhat surprising to find a normal, rather than very above-normal, concentration of glycosylated hemoglobin associated with a highly negatively charged fast hemoglobin variant. This patient was heterozygous for a fast hemoglobin variant; the high proportion of the variant hemoglobin (50%) and the lack of an abnormal HbA2 by cellulose acetate electrophoresis suggest a mutatio...

Objectives: The aim of the study was to incidence thalassemia minor by determining HbA2 levels in pregnant females attending Obstetrics and Gynaecology OPD husbands positive for beta-thalassemia trait. Methods: prospective spanning over 1½ years conducted Department Pathology 1020 who attended Government Medical College, Patiala antenatal check-up. any trimester without specific sign symptoms w...

Aksoy, M., DinVol, K., Erdem, S., Akgiin, T., and Diniol, G. (1972). Brit. J. industr. Med., 29, 56-64. Details of blood changes in 32 patients with pancytopenia associated with long-term exposure to benzene. A study was performed on 32 pancytopenic patients who had had longterm exposure to benzene. They had been subjected to high concentrations of benzene varying from 150 to 650 p.p.m. for fro...