BACKGROUND There have been few studies on the impact of viral etiology on the prognosis in patients with hepatocellular carcinoma (HCC). The aim of this study was to evaluate the clinical characteristics and survival of patients with viral hepatitis-associated HCC (V-HCC), compared to patients with HCC of non-hepatitis B, non-hepatitis C (NBNC-HCC) etiology. METHODS We performed a retrospecti...

Abstract Background Hepatocellular carcinoma (HCC) is one of the most common malignant cancers worldwide, and liver cancer has increased in mortality due to because it was detected at an advanced stages patients with dysfunction, making HCC a lethal cancer. Accordingly, we aim new targets for drug discovery using tumor spheroids. Methods Our comparative proteomic analysis cells grown culture as...

Abstract Background The tumor immunological microenvironment (TIME) has a prominent impact on prognosis and immunotherapy. However, the heterogeneous TIME mechanisms by which affects immunotherapy have not been elucidated in hepatocellular carcinoma (HCC). Methods A total of 2195 eligible HCC patients from TCGA GEO database were collected. We comprehensively explored different phenotypes its cl...

Background: Most patients with hepatocellular carcinoma (HCC) are diagnosed at late stages despite of improvement screening programs and lack effective diagnostic methods for cases preclinical HCC leads to a low rate early detection. Aldo-keto reductase family 1 member B10 (AKR1B10) is associated several types cancer. However, our knowledge, the significance AKR1B10 measurement in stage has poo...

coincidental occurrence of hepatocellular carcinoma (hcc) and cholangiocarcinoma, known as “collision tumors”, within a cirrhotic liver is rare. herein, we report a case of liver transplantation (lt) in a patient with such collision tumors. our patient was a 56-year-old woman with hepatitis c virus-related cirrhosis and 2 focal hepatic lesions, measuring 1.5 and 3 cm, in the liver segments 8 an...

conclusions serum stnfr-iiα could be used as a potential serum marker in diagnosing hcc among patients with hcv infection. results the serum level of stnfr-iiα was significantly higher in patients with hcc in comparison to the other groups. a positive correlation was found between the serum levels of stnfr-iiα and ast and alt in patients of group-ii. diagnosis of hcc among patients with hcv inf...

Abstract Background and purpose of the study Acoustic radiation force impulse elastography (ARFI) represents an innovative non-invasive tool for evaluation liver fibrosis, cirrhosis, early identification neoplastic nodules during follow-up cirrhotic patients; however, its diagnostic accuracy in prediction hepatocellular carcinoma (HCC) is still controversial. Purpose To assess potential role AR...

Purpose. The incidence of liver tumors is rising in USA. The purpose of this study was to evaluate liver oxido-reductive status in the presence of chronic liver disease and hepatocellular carcinoma (HCC). Methods. Glutathione species and ophthalmate (OA) concentrations were measured by LC-MS in processed plasma and red blood cells (RBC) from infected Woodchuck with hepatitis virus (WHV). Blood ...

The peak age of onset of hepatocellular carcinoma (HCC) is continually increasing worldwide. This study aims to evaluate whether there exists any significant difference in the clinicopathological features between younger- and elderly-HCC.1082 Consecutive patients with HCC who underwent liver resection at Liver Cancer Institute, Zhongshan Hospital, Fudan University from 1995 to 1998 were studied...