Hyperpolarization-activated, cyclic nucleotide sensitive (HCN) channels underlie the pacemaker current I(f), which plays an essential role in spontaneous cardiac activity. HCN channel subunits (HCN1-4) are believed to be modulated by additional regulatory proteins, which still have to be identified. Using biochemistry, molecularbiology and electrophysiology methods we demonstrate a protein-prot...

This paper reports the results of our use of Cavity Ring Down Spectroscopy to extend the study of highly excited vibrational states in HCN. We extend our previous study of the HCN isotopomer, reporting on some weaker bands between 17 500 and 19 500 cm. We also report spectra of overtone and combination bands with six, seven, and eight quanta of stretching vibration in the isotopomers HCN and HC...

A versatile, continuous wave, optical parametric oscillator is used in combination with photoacoustic spectroscopy for long-term trace gas experiments of volatile compounds emitted by biological samples. The optical parametric oscillator-based spectrometer (wavelength near 3 μm, 8-MHz linewidth, output power ∼1 W) is successfully tested for the detection of hydrogen cyanide (HCN) emission from ...

The architecture and operation of a trace hydrogen cyanide (HCN) gas sensor based on quartz-enhanced photo-acoustic spectroscopy and using a λ = 1.53 µm telecommu-nication diode laser are described. The influence of humidity content in the analyzed gas on the sensor performance is investigated. A kinetic model describing the vibrational to translational (V–T) energy transfer following the laser...

We have observed the 3-2 transitions of DCN and HC 15 N in a number of hot molecular cores previously surveyed by us with the interesting result that the DCN/HCN ratio is low, a few times 10 ?3 , in the hot cores. The abundance ratio of DCN/HCN is derived bothòn-core' andòo-core' and, in general is larger at thèoo-core' positions. Comparision with chemical models of these sources indicates that...

We present a sensitive 3 upper limit of 1.1% for the HNC/HCN abundance ratio in comet 73P/SchwassmannWachmann (fragment B), obtained on 2006May 10Y11, using Caltech Submillimeter Observatory (CSO). This limit is a factor of 7 lower than the values measured previously in moderately active comets at 1 AU from the Sun. Comet 73P/Schwassmann-Wachmann was depleted in most volatile species, except of...

The N/N ratio for N2 in the atmosphere of Titan was recently measured to be a factor of 2 higher than the corresponding ratio for HCN. Using a one-dimensional photochemical model with transport, we incorporate new isotopic photoabsorption and photodissociation cross sections of N2, computed quantum-mechanically, and show that the difference in the ratio of N/N between N2 and HCN can be explaine...

…upon being put into a solution of nicotine in sea water, the squid, 3 or 4 seconds, falls to bottom dish… Moore, 1919 Nicotine influences physiology organism via CNS.1 As confirmed also subiculum, may directly modulate hyperpolarization-activated cyclic nucleotide–gated (HCN) non-selective cation channel.2 The latter mirrors findings interneurons stratum oriens (SO) with axons terminating with...

[1] We report the first in situ measurements of hydrogen cyanide (HCN) and methyl cyanide (CH3CN, acetonitrile) from the Pacific troposphere (0–12 km) obtained during the NASA Transport and Chemical Evolution over the Pacific (TRACE-P) airborne mission (February–April 2001). Mean HCN and CH3CN mixing ratios of 243 ± 118 (median 218) ppt and 149 ± 56 (median 138) ppt, respectively, were measured...