Polycystic ovary syndrome (PCOS) is the most common reproductive-endocrine disorder affecting 10% of women. PCOS increases risk developing diabetes and cardiovascular disease (CVD). We have previously shown high-risk young women with without an atherogenic lipoprotein profile, this exacerbated in PCOS, elevated triglycerides (TG), remnant cholesterol apoB-lipoproteins. The aim study was to dete...

Background: Interleukin (IL)-23 and IL-27 are two IL-12-related cytokines which their function may dramatically influence the inflammatory response to tumor development. IL-12 and IL-27 seem to have antagonistic roles with IL-23 in tumor site. In this study, IL-23 and IL-27 mRNA expressions were analyzed in peripheral blood of patients with breast cancer and healthy volunteers using quantitativ...

Inflammation plays a pivotal role in the pathogenesis of atherosclerosis and coronary syndromes. Atherosclerosis is a complex multifactorial disorder. Data indicate that the complement proteins play a crucial role in the link between inflammation and atherogenesis. Thus, there is evidence supporting the role of complement activation in atherogenesis. Complement receptor 1 (CR1) is a membrane pr...

OBJECTIVE To determine the effects of type 1 diabetes mellitus on lung function and its gravity in relation to the duration of disease. METHODS We carried out this study in the Department of Physiology, College of Medicine and Diabetic Center, King Abdul-Aziz University Hospital, King Saud University, Riyadh, Saudi Arabia during the period 2003-2004. We randomly selected a group of 27 apparen...

The mucosal gene expression in rectosigmoid mucosa (RSM) in irritable bowel syndrome with diarrhea (IBS-D) is unknown. Our objectives were, first, to study mRNA expression [by RT(2) PCR of 19 genes pertaining to tight junctions, immune activation, intestinal ion transport and bile acid (BA) homeostasis] in RSM in IBS-D patients (n = 47) and healthy controls (n = 17) and study expression of a se...

BACKGROUND The costimulatory molecule OX40 and its ligand, OX40L, mediate key aspects of allergic airway inflammation in animal models of asthma, including eosinophilic airway inflammation, airway hyperresponsiveness, and T helper 2 polarization. We sought to examine OX40/OX40L and interleukin (IL)-4 expression in asthma across severities. METHODS Bronchial biopsies were obtained from 27 subj...

Irritable bowel syndrome (IBS) is often accompanied by extra‑intestinal symptoms, including fatigue and musculoskeletal pain. The present study aimed to investigate whether these symptoms were associated with markers of enterocyte disintegrity, endotoxemia and inflammation. Patients with IBS were recruited consecutively from our outpatient clinic (n=94) and compared with a group of healthy cont...

48 The mucosal gene expression in rectosigmoid mucosa (RSM) in irritable bowel syndrome 49 with diarrhea (IBS-D) is unknown. Our objectives were: first, to study mRNA expression (by 50 RT PCR of 19 genes pertaining to tight junctions, immune activation, intestinal ion transport 51 and bile acid homeostasis) in RSM in IBS-D patients (n=47) and healthy controls (n=17) and 52 study expression of a...