We studied the effect of cardiopulmonary bypass, transient acute coronary occlusion (2-5 minutes), prolonged coronary occlusion (> 60 minutes), and coronary reperfusion on the left ventricular diastolic pressure-volume curve, using an isovolumic working canine heart preparation in which heart rate, intraventricular volume, and aortic pressure were controlled. Cardiopulmonary bypass caused no si...

OBJECTIVE To describe the first clinical application of a novel tissue Doppler derived index of contractility, isovolumic acceleration (IVA), in the assessment of the ventricular myocardial force-frequency relation (FFR) in the univentricular heart (UVH). DESIGN Prospective study. SETTING Tertiary referral centre. INTERVENTIONS Non-invasive assessment of the myocardial FFR by tissue Doppl...

Cardiac remodeling occurs after cardiac pressure/volume overload or myocardial injury during the development of heart failure and is a determinant of heart failure. Preventing or reversing remodeling is a goal of heart failure therapy. Human cardiomyocyte Na(+)/K(+)-ATPase has multiple α isoforms (1-3). The expression of the α subunit of the Na(+)/K(+)-ATPase is often altered in hypertrophic an...

We previously found that luteolin (Lut) appeared to improve the contractility of cardiomyocytes during ischemia/reperfusion in rats. The enhancement was associated with the alteration in sarcoplasmic reticulum Ca2+-ATPase 2a (SERCA2a). This finding prompted us to consider if the mechanism worked in heart failure (HF). We studied the regulation of SERCA2a by Lut in failing cardiomyocytes and int...

Jeffery N. Carr, Thomas F. Kimball, Timothy E. Hewett, Gerald W. Dorn II, Walter J. Koch and Michael Hambleton, Harvey Hahn, Sven T. Pleger, Matthew C. Kuhn, Raisa Klevitsky, Andrew Cardiac Contractility and Attenuates Heart Failure Enhances β / α Pharmacologicaland Gene Therapy-Based Inhibition of Protein Kinase C Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2006 American Heart As...

Female rats that had been subjected to a moderate treadmill running program were compared with sedentary animals on the basis of heart weight, selected biochemical measurements, and heart function. Exercised animals maintained normal growth rate, and cardiac hypertrophy was not present. Left ventricular RNA, DNA, and cytochrome c levels were unchanged. Heart functional measurements obtained in ...

Phosphoinositide 3-kinases (PI3Ks) are important signaling proteins in the heart. Class IA PI3Ks (p110alpha, beta) are critical regulators of physiological heart growth and cell survival, and are generally considered to be beneficial for heart function. In contrast, activation of class IB PI3K(p110gamma) is detrimental for heart function, reducing cardiac contractility. This may have implicatio...

Microcinephotography was used to study heart development in a neural crest model of heart defects, that is, persistent truncus arteriosus, interrupted aortic arch, double outlet right ventricle, or single ventricle and tricuspid valve anomalies. These defects were created in chick embryos by ablation of premigratory neural crest destined for the aorticopulmonary and truncal septa, as well as th...

• Numerous workers have investigated the effects of stimulating the vagus nerves upon ventricular contractility in the mammalian heart. Many of these investigators" concluded that vagal stimulation has little or no influence on the contractility of the ventricles, while others^ deduced that it elicits a negative inotropic effect. Currently, the former opinion appears to be almost universally ac...

The purpose of this investigation was to study the relationships between the contractile behavior of the heart and myocardial prostaglandins. Using an open-chest model in rabbits, we assayed the left ventricular tissue content to prostaglandins (PG) E and F2 alpha at various intervals following acute pressure overload created by graduated aortic stenosis. The results suggest that the rabbits co...