In this paper we describe a methodology for developing smart card-based applications which accounts for both internal and external software production: on-card and client programs. This development methodology is based on the application of distributed object-oriented principles to Java Card. We design a model in which a card application is viewed as a remote object accessed through method invo...

Histone H1 and high-mobility group A (HMGA) proteins compete dynamically to modulate chromatin structure and regulate DNA transactions in eukaryotes. In prokaryotes, HMGA-like domains are known only in Myxococcus xanthus CarD and its Stigmatella aurantiaca ortholog. These have an N-terminal module absent in HMGA that interacts with CarG (a zinc-associated factor that does not bind DNA) to form ...

Caspase-associated recruitment domains (CARD) are protein-protein interaction modules found extensively in proteins that play important roles in apoptosis, NFkappaB activation, and cytokine regulation. In this study we identified a novel human protein, CARD-8, which contains a C-terminal CARD domain with high similarity to the CARD domain of caspase-1/ICE. We demonstrate that CARD-8 interacts p...

We use path integrals to calculate hedge parameters and efficacy of hedging in a quantum field theory generalization of the Heath, Jarrow, and Morton [Robert Jarrow, David Heath, and Andrew Morton, Econometrica 60, 77 (1992)] term structure model, which parsimoniously describes the evolution of imperfectly correlated forward rates. We calculate, within the model specification, the effectiveness...

This article revisits the Diffusion Operator Integral (DOI) variance reduction technique originally proposed in Heath and Platen (2002) extends its theoretical concept to pricing of America...

We describe a family of graphs with queue-number at most 4 but unbounded stack-number. This resolves open problems Heath, Leighton and Rosenberg (1992) Blankenship Oporowski (1999).

Nucleotide-binding and oligomerization domain-containing protein 1 (NOD1) and NOD2 are cytosolic pattern-recognition receptors (PRRs) composed of an N-terminal caspase activation and recruitment domain (CARD), a central NACHT domain and C-terminal leucine-rich repeats (LRRs). They play a vital role in innate immune signaling by activating the NF-κB pathway via recognition of peptidoglycans by L...

BACKGROUND The quality of epilepsy care has often been noted to be poor and fragmentary. Most people with epilepsy are solely under the care of their general practitioner (GP). Many patients report medication side-effects and poor seizure control. Most GPs accept responsibility for epilepsy care; however, many report problems with knowledge of epilepsy and nearly all support guidance on epileps...