Theophylline-7-acetic acid (7-TAA) derivatives with several amino acids were screened for antiproliferative effects on acute (HL-60) and chronic (K-562) myeloid leukemia cells as well as on non-malignant cells derived from embryonic human kidney (HEK 293T). The anti-proliferative effects (IC50) were revealed at relatively high concentrations, between 330.4 and 1051.9 μM, but the tested compound...

An important question in the pathophysiology of dominantly inherited diseases, such as channelopathies, is the level of expression of the mutant protein. In our study, we address this issue by comparing the gating defects of two human muscle NaF channel mutants (R1448C and R1448P) causing paramyotonia congenita in native muscle specimens from two patients with those of the same mutant recombina...

Kcv (K(+) Chlorella virus) is a miniature virus-encoded K(+) channel. Its predicted membrane-pore-membrane structure lacks a cytoplasmic C-terminus and it has a short 12 amino acid (aa) cytoplasmic N-terminus. Kcv forms a functional channel when expressed in human HEK 293 cells. Deletion of the 14 N-terminal aa results in no apparent differences in the subcellular location and expression level ...

Koronavirüs hastal??? (COVID-19) 2019 y?l?nda ilk olarak Çin'in Wuhan kentinde görülmü?, ard?ndan Dünya Sa?l?k Örgütü (WHO) taraf?ndan, yüksek ölüm oranlar?yla, pandemi ilan edilmi?tir. Bunun tüm Dünya’da ve ülkemizde ba?ta sa?l?k çal??anlar? olmak üzere risk alt?ndaki bireylerin korunmas?yla ilgili h?zla birçok kaynaktan çe?itli bilgiler payla??lmaya ba?lan?lm??t?r. COVID-19 pandemisi teorik e...