A plasmid bearing both a replication initiation region and a matrix attachment region is spontaneously amplified in transfected mammalian cells and generates plasmid repeats in the extrachromosomal double minutes (DMs) or the chromosomal homogeneously staining region (HSR). Generally, the repeat sequences are subject to repeat-induced gene silencing, the mechanism of which remains to be elucida...

Calcium release from sarcoplasmic reticulum vesicles presumably derived from longitudinal tubules (LSR) and terminal cisternae (HSR) of rabbit skeletal muscle was investigated by dual wavelength spectrophotometry using the calcium-indicator antipyrylazo III. In 120 mM KCl, 5 mM MgCl2, 30 microM, CaCl2, 50 microM MgATP, 100 microM antipyrylazo III, 40 mM histidine (pH 6.8, 25 degrees C), LSR and...

Wireless communication for high-speed railways (HSRs) that provides reliable and high data rate communication between the train and trackside networks is a challenging task. It is estimated that the wireless communication traffic could be as high as 65 Mbps per high-speed train. The development of such HSR communications systems and standards requires, in turn, accurate models for the HSR propa...

This paper explores the effect of impeller design on the chaotic mixing in a helical ribbon mixer. Numerical simulations using the Smoothed Particle Hydrodynamics (SPH) method are used to solve for the fluid flow around the moving impellor. The mixing flow is visualised by extracting the hyperbolic Lagrangian Coherent Structures (LCS) of the flow from the Finite-Time Lyapunov Exponent (FTLE) fi...

BACKGROUND The presence of the HLA-B*57:01 allele in HIV-infected subjects is associated with a higher risk of abacavir-associated hypersensitivity reaction (ABC HSR). HLA-B*57:01 allele prevalence varies in different populations, but HLA-B*57:01 testing with immunological confirmation has had a negative predictive value for ABC HSR between 97 and 100%. METHODS In the ASSURE study (EPZ113734)...

39 40 Within public policy and academic discourses, high-speed rail (HSR) is presented as a way of 41 achieving “smarter” or more sustainable forms of growth. Realizing this promise requires 42 coordinated policy efforts across levels of government and at different moments along a project’s 43 timeline. The research presented here makes use of a systems perspective to study the barriers to44 an...

BACKGROUND Despite its importance in providing evidence for health-related policy and decision-making, an insufficient amount of health systems research (HSR) is conducted in low-income countries (LICs). Schools of public health (SPHs) are key stakeholders in HSR. This paper, one in a series of four, examines human and financial resources capacities, policies and organizational support for HSR ...

The distribution of HSR-903, a new quinolone antibacterial agent, to the brain after i.v. administration to rats was low compared with that to other tissues. The blood-brain barrier permeability to HSR-903 determined by the brain perfusion method was low, and increased nonlinearly with increasing concentration of HSR-903 in the perfusate. When the brain-to-plasma concentration ratio (Kp, brain)...

Gender-the socially constructed roles, behaviours, activities and attributes that a given society considers appropriate for males, females and other genders-affects how people live, work and relate to each other at all levels, including in relation to the health system. Health systems research (HSR) aims to inform more strategic, effective and equitable health systems interventions, programs an...