BACKGROUND Endothelium-derived nitric oxide plays a crucial role in the regulation of vascular tone and the development of cardiovascular disease. The endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA) has emerged as a novel cardiovascular risk factor. ADMA appears to be an independent predictor for cardiovascular and overall mortality. However, the majority of studie...

Proteolytic activity in whole blood may lead to release of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA). We investigated the role of the human erythrocyte in storage and generation of ADMA in healthy controls (n = 36) and critically ill patients (n = 38). Both free and total (sum of free and protein-incorporated) ADMA were measured. Upon incubation of intact...

The title compound, [Zn(C(6)H(4)NO(3))(N(3))], has been prepared by the reaction of nicotinate N-oxide acid, zinc(II) nitrate and sodium azide. The Zn atom is five coordinated by two azide anions and three nicotinate N-oxide ligands. Each nicotinate N-oxide bridges three Zn atoms, whereas the azide bridges two Zn atoms, resulting in the formation of a two-dimensional metal-organic polymer devel...

The Glauciumpaucilobum Freyn population of the Golestan forest contained three major alkaloids; protopine (0.5%), ?-allocryptopine (0.2%), corydine (0.1 %), and six minor alkaloids; N-rnethyllind carpine (0.006), bulboca 'nine (0.04%), 4-hydroxy bulbocapnine (0.001%), Ismorycline (0.04%), arosine (0%02%) and corydine-?-Noxide (0.003%). N-methyllindcrapine, 4-hydroxybulbocapnine and corydine-...

The behavioral-state related firing of mesopontine cholinergic neurons of the laterodorsal tegmental nucleus appears pivotal for generating both arousal and rapid-eye-movement sleep. Since these neurons express high levels of nitric oxide synthase, we investigated whether their firing increases local extracellular nitric oxide levels. We measured nitric oxide in the laterodorsal tegmental nucle...