BACKGROUND Activated prothrombin complex concentrate (aPCC) and recombinant Factor VIIa (rFVIIa) are 2 bypassing agents commonly used for treating acute bleeds in hemophiliac patients with inhibitors. A wide range of efficacy rates for aPCC and rFVIIa have been reported in a number of single-armed and randomized controlled comparative studies. OBJECTIVE The aims of this study were to compare ...

One of the best procedures to prevent haemarthrosis in haemophilia has been radioactive synovectomy (radiosynoviorthesis). Since 1976 we have performed 119 radiosynoviortheses in 110 patients, aged from 3 to 40 years (mean 10), and of whom 71 were under 12 years of age. The knees were injected in 71, elbow in 29, ankles in 16, and shoulders in 3 cases. Clinical results of the procedure gave exc...

Kai ALONS, MD, DMD, Manon T. P. NAPHAUSEN, MD, DMD, Johannes W. VON DEN HOFF, PhD, Peter M. VAN DER KRAAN, PhD, Jaap C. MALTHA, PhD, Andor A. VELTIEN, BSc, Arend HEERSCHAP, PhD, Philip A. VAN DAMME, DMD, MD, PhD Department of Oral and Maxillofacial Surgery (Chair: Prof. Dr. S.J. Bergé), Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; Department of Orthodontics and Oral Bi...

We have investigated a prospective series of 100 acute traumatic haemarthroses of the knee in a general non-athletic population. All the patients had normal radiographs and an aspiration which confirmed the haemarthrosis, before undergoing ligament testing and an arthroscopic examination under anaesthesia. Only one patient had no serious pathology; in the other 99 a total of 193 lesions were re...

Replacement of the congenitally deficient factor VIII or IX through plasma-derived or recombinant concentrates is the mainstay of treatment for hemophilia. Concentrate infusions when hemorrhages occur typically in joint and muscles (on-demand treatment) is able to resolve bleeding, but does not prevent the progressive joint deterioration leading to crippling hemophilic arthropathy. Therefore, p...

INTRODUCTION Pigmented villonodular synovitis is a disease which affects the synovial joints and tendon sheaths. Although the exact aetiological factors are not known, we believe that recurrent haemarthrosis has a role in the aetiology of this condition. CASE PRESENTATION A 62-year-old Caucasian man presented with gradually worsening pain and stiffness in his right knee. The patient was on an...

INTRODUCTION Femoral or patellar osteochondral fractures complicating patellar dislocation are more frequently observed in adolescents than in adults. These incidental lesions of vulnerable joint cartilage are often neglected in the initial phase, which is regrettable given their good capacity for healing after repositioning. The objective of this study was to investigate the characteristics an...