Systemic capillary leak syndrome (SCLS), also known as Clarkson’s disease, is a rare and potentially lethal condition characterized by hypotension, hemoconcentration, hypoalbuminemia; however, the cause of SCLS still uncertain. We present case 62-year-old male with flu-like symptoms who presented to emergency department shock. Initial evaluation revealed hypoalbuminemia, acute kidney failure, p...

Dengue is a prevalent arthropod-borne viral disease in tropical and subtropical areas of the globe. clinical manifestations include asymptomatic infections; undifferentiated fever; dengue fever, which characterized by headache, retroorbital pain, myalgia, arthralgia; severe form denominated hemorrhagic fever/dengue shock syndrome, hemoconcentration, thrombocytopenia, bleeding tendency. However,...

Acute pancreatitis remains a serious disease. In 2009, acute pancreatitis accounted for more than 274,000 hospital discharges, (ranking first among all gastro-intestinal discharge diagnoses), with an aggregate cost of more than $2,500,000 (the costliest of all gastro-intestinal disorders). It also ranked 14 th among causes of death from gastrointestinal and liver diseases [1]. Mortality from ac...

Background and AimsPlasma refill rates can be estimated by combining measurements of urine output with relative blood volume profiles. Change in plasma could guide decongestive loop diuretic therapy acute heart failure.ObjectivesTo assess average profiles generated from two or three follow-up obtained hours after administration subjects without baseline congestion.MethodsA systematic review Eng...

Background: Empagliflozin reduces the risk of hospitalization for heart failure in patients with type 2 diabetes and cardiovascular disease. We sought to elucidate effect empagliflozin as an add-on therapy on decongestion renal function admitted acute decompensated failure. Methods: The study was terminated early due COVID-19 pandemic. enrolled 59 consecutive Patients were randomly assigned rec...

UNLABELLED With over 3.5 billion people at risk and approximately 390 million human infections per year, dengue virus (DENV) disease strains health care resources worldwide. Previously, we and others established models for DENV pathogenesis in mice that completely lack subunits of the receptors (Ifnar and Ifngr) for type I and type II interferon (IFN) signaling; however, the utility of these mo...