Functional Magnetic Resonance Imaging (fMRI) is one of the most popular neuroimaging methods for investigating the activity of the human brain during cognitive tasks. As with many other neuroimaging tools, the group analysis of fMRI data often requires a transformation of the individual datasets to a common stereotaxic space, where the different brains have a similar global shape and size. Howe...

Treatment of murine resident peritoneal macrophages with macrophage-CSF (M-CSF) up-regulated the synthesis of a discrete set of proteins, including a 26-kDa protein (p26). The sequence of 20 NH2-terminal amino acids of the purified p26 was identical with the mouse homolog of a human IgE-dependent histamine-releasing factor (HRF). Among macrophage activators tested (M-CSF, granulocyte-macrophage...

IgE-mediated activation of mast cells and basophils underlies allergic diseases such as asthma. Since Thueson et al. first described an activity from cultured peripheral blood mononuclear cells that induced the release of histamine from basophils [1], histamine-releasing activities have been studied for more than 30 years. In addition to several cytokines and chemokines with this activity, an u...

Introduction: Simultaneous acquisition of EEG and functional MRI (fMRI) data has proven to be a powerful technique to investigate the location and dynamics of epileptiform networks associated with interictal epileptic discharges (IED). However, in most analyses for IED, EEG dominates fMRI, i.e. the EEG determines the onsets of the IED events in the general linear model (GLM) fMRI analysis (1, 2...

Transcription factors of the bHLH-PAS protein family are important regulators of developmental processes such as neurogenesis and tracheal development in invertebrates. Recently a bHLH-PAS protein, named trachealess (trl) was identified as a master regulator of tracheogenesis. Hypoxia-inducible factor, HIF-1 alpha, is a vertebrate relative of trl which is likely to be involved in growth of bloo...

BACKGROUND Low levels of physical activity (PA) and poor fitness tend to predict a decline in mobility. The current study investigated whether PA modifies the predictive value of health-related fitness (HRF) tests on difficulty in walking 2 km (WD). METHODS PA was assessed by self-reported questionnaires in 1990 and 1996. Subjects age 55 to 69 years and free of self-reported WD participated i...

Objective To investigate the modulated effects of HRF on cyclooxygenase isoform expression and its activity, using the human umbilical vein endothelial cell (HUVEC) model induced by interleukin-1 beta (IL-1β). Methods Cells were treated with indomethacin (positive control), HRF, and its components at various concentrations prior to treatment with IL-1β at 24 h. Cell viability was determined b...

Numerous studies have demonstrated that TCTP/HRF is a unique cytokine, modulating the release of inflammatory mediators from various cell types including cells involved in allergic phenomena. Despite the absence of a leader sequence in its NH2-terminus, TCTP/HRF is regarded as a secreted protein found outside of cells as well as in fluids from allergic patients and parasitic organisms. Recent s...

One of the most consistent electrophysiological deficits reported in the schizophrenia literature is the failure to inhibit, or properly gate, the neuronal response to the second stimulus of an identical pair (i.e., sensory gating). Although animal and invasive human studies have consistently implicated the auditory cortex, prefrontal cortex and hippocampus in mediating the sensory gating respo...

In this article, we present a Markov Bernoulli Lomax (MB-L) model, which is obtained by countable mixture of and distributions, with decreasing unimodal hazard rate function (HRF). The new model contains Marshall- Olkin distributions as special case. mathematical properties, behavior probability density (PDF), HRF, rth moments, moment generating (MGF) minimum (maximum) Markov-Bernoulli Geometri...