This study reports the optical characterization and quantitative oximetry of human breast cancer using spectrally-resolved images collected with a broadband, continuous-wave optical mammography instrument. On twenty-six cancer patients, we collected two-dimensional optical mammograms and created maps of the concentrations of hemoglobin, water, and lipids, as well as the oxygen saturation of hem...

BACKGROUND Detecting failing tissue flaps before they are clinically apparent has the potential to improve postoperative flap management and salvage rates. This study demonstrates a model to quantitatively compare clinical appearance, as recorded via digital camera, with spatial frequency domain imaging (SFDI), a noninvasive imaging technique using patterned illumination to generate images of t...

Almost all diseases, especially cancer and diabetes, manifest abnormal oxygen metabolism. Accurately measuring the metabolic rate of oxygen (MRO(2)) can be helpful for fundamental pathophysiological studies, and even early diagnosis and treatment of disease. Current techniques either lack high resolution or rely on exogenous contrast. Here, we propose label-free metabolic photoacoustic microsco...

PURPOSE OF THE STUDY To determine the effects of acetylcholine and spermineNONOate--a NO donor--on RBC membrane and oxygen carrying properties. MATERIAL AND METHODS Aliquots of venous blood from eleven healthy subjects were incubated with ACh 10(-3) M, ACh 10(-5) M, spermineNONOate 10(-5) M and spermineNONOate 10(-4) M. The following parameters were determined: erythrocyte aggregation and def...

The use of the pulse oximeter to estimate oxygen saturation has revolutionized monitoring capabilities in medicine. However, there can be circumstances in which there is a discordance between oxygen saturation measurements via pulse oximeter (SpO2) and actual arterial oxygen levels (PaO2). In these situations, there is a possibility the patient could have a variant hemoglobin as the etiology of...

BACKGROUND The oxygen saturation of haemoglobin is reduced in high altitude-living organisms. Increase in the hematocrit is responsible for rise in the hemoglobin concentration so that the oxygen carrying capacity in the hypobaric hypoxic subject is elevated. OBJECTIVES To compare two different high altitude populations, in order to study the relationship between arterial oxygen saturation an...

Aim. Chronic maternal iron deficiency anemia has been found to be related with preterm delivery, low birth weight and intrauterine growth retardation. The potential detrimental effects of maternal anemia on the transplacental fetal oxygen extraction during labor have not been investigated yet. Method. Upon the spontaneous initiation of delivery among 32 term pregnant women, half of them with he...

There is general agreement that the fall in haemoglobin after birth is an expression of the increased oxygen saturation of the blood when lung replaces placenta as a source of oxygen. We have sought to express this idea concretely, to show that the changes which occur in the form and number of red cells after birth are due to variations in the erythropoietic activity of the marrow, and finally ...

To the Editor: In the April issue of RESPIRATORY CARE, Amalakanti and Pentakota1 present a comparison of arterial oxygen saturation values between a 2-wavelength pulse oximeter and blood gas multi-wavelength hemoximetry in COPD subjects with acute respiratory failure. The authors conclude that the 2-wavelength pulse oximeter significantly overestimates arterial oxygen saturation and that COPD a...

Microcirculatory changes and oxidative stress have long been associated with acute kidney injury. Despite substantial progress made by two-photon microscopy of microvascular responses to injury in rodent models, little is known about the underlying blood oxygen delivery tissue metabolism. To fill this gap, we developed a label-free imaging technique based on photoacoustic microscopy, which enab...