BACKGROUND/AIM The altered cellular repair capacity plays a critical role in genomic instability and carcinogenesis. We aimed at evaluating the contribution of the polymorphic variant in apurinic/apyriminidinic endonuclease (APEX1) gene to its mRNA and protein levels and the risk of endometriosis. PATIENTS AND METHODS In the current case-control study, 153 endometriosis patients and 636 non-e...

Endometriosis is a common, chronic disease. Patients typically present with pelvic pain, infertility, and/or an adnexal mass. Results from the limited number of studies that have been published indicate that the true prevalence of endometriosis, along with the associated infertility, has been increasing. Debates about infertility management arise from the contradiction between the contraceptive...

OBJECTIVE To identify associations between presence of endometriosis and oocyte defects, embryo developmental potential, and cycle outcomes. METHODS This study looked into the impact of endometriosis on oocyte and embryo quality, and blastocyst formation probability. Endometriosis was also correlated with cycle characteristics. In order to avoid age-related bias, in the first analysis only pa...

BACKGROUND Endometriosis, a common gynaecological disease, is characterized by local and systemic inflammation, which may cause infertility and consequently, increased utilization of assisted reproduction technology (ART). We aimed to estimate the risk for preterm birth, small-for-gestational-age (SGA) birth, stillbirth, Caesarean section, pre-eclampsia and antepartal haemorrhage among women wi...

The objective was to develop recommendations for the diagnosis and treatment of endometriosis and its associated symptoms. A working group was convened comprised of practising gynaecologists and experts in evidence-based medicine from Europe, as well as an endometriosis self-help group representative. After reviewing existing evidence-based guidelines and systematic reviews, the expert panel me...

Treatment strategies for the infertile couple with endometriosis must be based on the specific situation. Traditional medical therapy for endometriosis, such as progestins, danazol, and GnRH agonists, have been shown to have little impact on enhancing spontaneous pregnancy rates despite well described beneficial effects on reducing pain. For the young women with only minimal or mild endometrios...

Background: Diagnosis and management of pre-rupture stage of the pregnant horn are difficult and usually missed on a routine ultrasound scan. Furthermore, most cases are detected after rupture of pregnant horn. Case: We presented a 28-year-oldG2 L1 woman with diagnosis of RHP at 14 weeks of gestation. She was initially diagnosed with a normal intrauterine pregnancy, whereas a pregnancy in a rig...

Diagnosis and management of pre-rupture stage of the pregnant horn are difficult and usually missed on a routine ultrasound scan. Also most cases are detected after rupture of pregnant horn. We presented a 28-year-oldG2 L1 woman with diagnosis of rudimentary horn pregnancy (RHP) at 14 weeks of gestation. We diagnosed her with a normal intrauterine pregnancy, whereas a pregnancy in a right-sided...

Background: Chemokines, proteins that operate within the body's immune system, play numerous roles in menstruation, bacterial infection, implantation of embryos, and the maintenance of early pregnancy. They are also strongly related to the pathogenesis of endometriosis. Materials and Methods: This is review article that were indentifical by computer search of MEDLINE (1984- 2013). Results:...