The term idiopathic noncirrhotic portal hypertension (INCPH) has been recently proposed to replace terms, such as hepatoportal sclerosis, idiopathic portal hypertension, incomplete septal cirrhosis, and nodular regenerative hyperplasia, used to describe patients with a hepatic presinusoidal cause of portal hypertension of unknown etiology, characterized by features of portal hypertension (esoph...

In this review we summarize the role of liver biopsy, transient elastography and hepatic venous pressure gradient (HVPG) in the diagnosis and monitoring of patients with liver cirrhosis. Transient elastography is useful for the non-invasive diagnosis of cirrhosis, but relevant information is lost if it is used as a dichotomous test. The development of clinically significant portal hypertension ...

The development of liver cirrhosis and portal hypertension (PH), one of its major complications, are structural and functional alterations of the liver, occurring in many patients with chronic liver diseases (CLD). Actually the progressive deposition of hepatic fibrosis has a key role in the prognosis of CLD patients. The subsequent development of PH leads to its major complications, such as as...

BACKGROUND Hepatic decompensation in cirrhosis heralds an accelerated course with poor survival. An increase in hepatic venous pressure gradient (HVPG), rather than surrogate tests of liver function, appears to be the sole predictor of decompensation after surgical resection. We propose that hepatic sinusoidal walls become less elastic as cirrhosis progresses. Decompensation signals the develop...

The aim of this work is to analyze quantitative data magnetic resonance ASL-perfusion the liver at admission and follow up patients with viral cirrhosis. study included 34 cirrhosis: 23 (67.6 %) men 11 (32.4 women. All subjects underwent abdominal ultrasound Dopplerography vessels, shear wave elastography, Arterial spin Labeling (ASL) — Perfusion by imaging. Post-processing images was carried o...

OBJECTIVE To determine the efficacy of Rifaximin in prevention of repeated episodes of hepatic encephalopathy in patients with liver cirrhosis as compared to placebo. STUDY DESIGN Triple-blind, randomized placebo-controlled trial. PLACE AND DURATION OF STUDY Department of Gastroenterology-Hepatology, Shaikh Zayed Hospital, Lahore, from October 2012 to April 2013. METHODOLOGY Patients in r...

Radiation therapy (RT) has been emerging as one of the palliative treatments for locally advanced hepatocellular carcinoma (HCC). However, hepatic toxicity is a major obstacle in radiotherapy for HCC. The purpose of this study is to identify proteins indicating radiation-induced hepatic toxicity in cirrhotic rats, which can be used as possible biomarkers. Liver cirrhosis was induced in Wistar r...

OBJECTIVE Parkinsonism and other movement disorders have previously been reported in the acquired hepatocerebral degeneration associated with portosystemic shunting. However, there is no study to date about their prevalence as has been noted in general practice. METHODS One hundred and forty-three patients with hepatic cirrhosis from the gastroenterology clinic and internal medicine wards wer...

A method of sequential extraction of /3-glucuronidase-hydrolyzed urine, which permits the assessment of alternative pathways of corticosteroid excretion, was employedto study urine samplesfrom normal subjects and from patients with hepatic cirrhosis. In patients with hepatic cirrhosis there is a decrease in the excretion ef methylene dichloride-soluble 17-hydroxycorticosteroids; this decrease i...

In cirrhosis, the phagocytic function of the reticuloendothelial system (RES) is decreased. In order to investigate the mechanisms of the hepatic reduced phagocytic activity present in cirrhosis, the hepatic and splenic uptake of 51Cr sheep red blood cells (SRBC) and of colloidal carbon was measured in three groups of Sprague-Dawley rats. Group 1 consisted of 42 control rats, group 2 of 36 rats...