نتایج جستجو برای: hepatitis b virus x protein

تعداد نتایج: 2767092  

2017
Qingzhu Gao Kai Wang Ke Chen Li Liang Yaqiu Zheng Yunzhi Zhang Jin Xiang Ni Tang

Hepatitis B virus X protein plays a crucial role in the pathogenesis of hepatocellular carcinoma. We previously showed that the tumor suppressor ARID2 inhibits hepatoma cell cycle progression and tumor growth. Here, we evaluated whether hepatitis B virus X protein was involved in the modulation of ARID2 expression and hepatocarcinogenesis associated with hepatitis B virus infection. ARID2 expre...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1999
U Protzer M Nassal P W Chiang M Kirschfink H Schaller

Hepatitis B viruses specifically target the liver, where they efficiently infect quiescent hepatocytes. Here we show that human and avian hepatitis B viruses can be converted into vectors for liver-directed gene transfer. These vectors allow hepatocyte-specific expression of a green fluorescent protein in vitro and in vivo. Moreover, when used to transduce a type I interferon gene, expression o...

Journal: :hepatitis monthly 0
rosa cristina coppola department of public health, clinical and molecular medicine, university of cagliari, italy +39-706753104, coppola@medicina. unica.it; department of public health, clinical and molecular medicine, university of cagliari, italy +39-706753104, coppola@medicina. unica.it rosa cristina coppola department of public health, clinical and molecular medicine, university of cagliari, italy +39-706753104, [email protected]; department of public health, clinical and molecular medicine, university of cagliari, italy +39-706753104, [email protected] angelo meloni department of public health, clinical and molecular medicine, university of cagliari, italy +39-706753104, coppola@medicina. unica.it marcello campagna department of public health, clinical and molecular medicine, university of cagliari, italy +39-706753104, coppola@medicina. unica.it

Journal: :archives of clinical infectious diseases 0
afshin hooshyar department of gastroenterology, imam khomeini hospital, ardabil university of medical sciences, ardabil, ir iran shahram habibzadeh department of infectious disease, imam khomeini hospital, ardabil university of medical sciences, ardabil, ir iran; department of infectious disease, imam khomeini hospital, ardabil university of medical sciences, ardabil, ir iran. tel: +98-9144519670, fax: +98-4515510057 nasrin ghasemi department of internal medicine, imam khomeini hospital, ardabil university of medical sciences, ardabil, ir iran abbas yazdanbod department of gastroenterology, imam khomeini hospital, ardabil university of medical sciences, ardabil, ir iran sirus sohrabi department of emergency medicine, shahid beheshti university of medical sciences, tehran, ir iran nasrollah maleki department of internal medicine, imam khomeini hospital, ardabil university of medical sciences, ardabil, ir iran

background: more than 350 million people are chronic carriers of hepatitis b virus (hbv) and because of the high hbv-related morbidity and mortality, the global disease burden of hbv is substantial. in patients with hbeag–negative chronic hepatitis b (chb) with serum alanine aminotransferase (alt) levels, 1-2 × upper limit of normal (uln) and hbv dna load of 10000 to 100000 copies/ml, liver bio...

Journal: :hepatitis monthly 0
bo qin shaoxing centre for disease control and prevention, shaoxing, china; state key lab of virology, wuhan institute of virology, chinese academy of sciences, wuhan, china; shaoxing center for disease control and prevention, shaoxing, china. tel: +86-57588137362, fax: +86-57588137333 bo zhang state key lab of virology, wuhan institute of virology, chinese academy of sciences, wuhan, china xiaodong zhang college of life science, shaoxing university, shaoxing, china tingting he shaoxing centre for disease control and prevention, shaoxing, china wenying xu shaoxing centre for disease control and prevention, shaoxing, china lijun fu shaoxing centre for disease control and prevention, shaoxing, china

background nucleus(t)ide analogs (nas), containing lamivudine (lmv), adefovir dipivoxil (adv), endeavor (etv), telbivudine (ldt), and tenofovir (tdf) are widely used for the treatment of chronic hepatitis b (chb), but long term anti-hepatitis b virus (hbv) therapy with nas may give rise to the emergence of drug-resistant viral mutants. objectives this study aimed to find and identify some new r...

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