BACKGROUND Hepatocellular carcinoma is the fifth most common malignant cancer in the world. Liver resection and local ablation are the most effective therapeutic approaches for most HCC patients. Recurrence after curative therapy is very common. Some studies reveal that IFNs have an effect on recurrence. While the opinion is disagreement. OBJECTIVES The aim of this meta-analysis was to evalua...

Objective(s): Hepatocellular carcinoma (HCC) is one of the most significant health condition around the world. As the only curative therapies, liver transplantation and surgical resection are the clinical treatments of HCC. Due to the systemic toxicity and severe side effects of these treatments, it is vital to establish new therapeutic approaches. The present study ai...

the imaging of hepatocellular carcinoma (hcc) is challenging and plays a crucial role in the diagnosis and staging of the disease. a variety of imaging modalities, such as ultrasound, computed tomography (ct), magnetic resonance imaging (mri) and nuclear medicine are currently used in evaluating patients with hcc. although the best option for the treatment of these cases is hepatic resection or...

this report describes a 66-year-old male who had a long history of hepatitis b virus (hbv) infection. he was found hepatocellular carcinoma (hcc) 5 months after lamivudine resistance mutation and then received a successful hepatectomy. three years later, hepatitis b envelope antigen seroconversion was achieved and nucleoside analogs were discontinued. after the withdrawn of antiviral treatment,...

Hepatocellular carcinoma (HCC) and colorectal cancer (CRC) are among the most common cancers across the world. Therefore, identifying the potential molecular mechanisms that promote HCC and CRC progression and metastasis are urgently needed. Spermidine/spermine N1-acetyltransferase (SSAT) is a catabolic enzyme that acetylates the high-order polyamines spermine and spermidine, thus decreasing th...

The incidence of non-alcoholic steatohepatitis (NASH)-related hepatocellular carcinoma (HCC) is increasing annually as the metabolic syndrome factors increase. This study aimed to analyze involvement periodontopathic bacteria in NASH-related HCC (NASH-HCC). Questionnaire investigation, periodontal examination, medical and specimen collection (saliva, mouth-rinsed water, peripheral blood) were p...

Girdin has been proven to play a vital role in the process of proliferation, apoptosis, and invasion in various cancer cells, yet the underlying molecular mechanism in primary hepatocellular carcinoma (HCC) has not yet been clarified. Thereafter, we performed immunohistochemistry to detect the expression of Girdin in 40 primary HCC tissues and 30 matched adjacent tissues using hepatic carcinoma...

Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer mortality globally. In addition, most patients present in advanced stages with limited curative treatment options. Therefore, multidisciplinary often warranted. Here, we report a patient HCC and severe arterioportal shunt (APS) who was treated approach comprising interventional radiology procedures, apatinib camrelizumab. Afte...

conclusions we showed that in treatment of patients with unresectable hepatocellular carcinoma, tace significantly improved the disease and the overall survival rate. also, we introduce the tumor size, serum alp level, and number of liver involved segments as prognostic factors of the procedure. finally, tace can be recommended as the initial treatment for unresectable hcc patients. background ...

We report the case of a 68-year-old man with advanced hepatocellular carcinoma (HCC) multiple bone metastases (BM) treated tyrosine kinase inhibitors. Despite an insufficient disease control on BM progression free survival (PFS) 6 months, sorafenib was not discontinued and radiation therapy (RT) sessions palliative purpose were performed. Thanks to this aggressive radiotherapy approach in order...