نتایج جستجو برای: her 2 receptor
تعداد نتایج: 3013749 فیلتر نتایج به سال:
In experimental models, human epidermal growth factor receptor-2 (HER-2) amplification leads to estrogen independence and tamoxifen resistance in estrogen receptor (ER)-positive human breast cancer cells. Some but not all reports suggest an association between HER-2 positivity and hormone independence in breast cancer patients. This study aimed to evaluate the antiproliferative effects of endoc...
The human epidermal growth factor receptor 2 (HER-2/neu) is a biomarker, recognized as a valuable prognostic and predictive factor for breast cancer. In approximately 20% of primary breast cancers, the HER2/neu protein is over-expressed. The effect of this over-expression is an increase in receptor mediated intracellular signalling, directing the cancer cells into fast proliferation, which resu...
The present study aimed to determine whether the expression of microRNA (miR)-10b was correlated with the molecular subtypes of early invasive ductal carcinoma of the breast. In situ hybridization was used to detect the expression of miR-10b in 193 patients diagnosed with early invasive ductal carcinoma. Immunohistochemistry was performed to evaluate the expression of estrogen receptor (ER)-α, ...
Members of the epidermal growth factor receptor family of tyrosine kinases, including epidermal growth factor receptor, c-erbB-2 (HER-2), c-erbB-3 (HER-3), and c-erbB-4 (HER-4), can be coexpressed at different levels in nonhematopoietic tissues. Amplification and overexpression of HER-2 is found in approximately one-third of cancers that arise in the breast and ovary. In our previous studies, h...
1.1 erbB family HER-2 is a member of the erbB family of receptor tyrosine kinases. Epidermal Growth Factor Receptor (EGFR) was first identified as the cellular homolog of the transduced oncogene of the avian retroviruses such as avian ERythroBlastosis virus, which causes erythroleukemia and fibrosarcoma and gives rise to the family name (erbB). EGFR, as its name implies, was shown by Stanley Co...
Introduction: Breast cancer is the most common cancer in women and leading cause of cancer death in women. In India its incidence is rapidly rising. Present study was aimed to study pattern of expression of Hormone receptor and Her-2/neu in invasive breast carcinoma and to correlate ER PR status and Her-2/neu expression with various Clinicopathological aspects. Method: The present study was car...
مقدمه: سرطان پستان شایع ترین بدخیمی زنان در دنیا با بیش از یک میلیون مورد جدید در سال می باشد. رشد سرطان پستان در انسان اغلب با هورمون های استروئیدی نظیر استروژن و فاکتورهای رشد پپتیدی تنظیم می شود که با گیرنده های فاکتور رشد اپیدرمی یک و دو در همکنشی دارند. سطح گیرنده های هورمونی در بافت طبیعی پستان پایین است ولی در دوسوم موارد سرطان پستان سطح این گیرنده ها بالا تر می باشد. روش بررسی: در این...
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