INSULIN resistance in association with primary haemochromatosis has been reported on several occasions previously (Allen and Constam, 1929; Root, 1929; Wood and Fitzhugh, 1929; Engel, 1934; Eskind, Franklin and Lowell, 1953; Colwell and Weiger, 1956; Darnaud, Denard, Moreau, Voisin and Pujol, 1958; Uhry, Marcel and Cohen, 1958; Justin-Besancon, Pequignot, Deuil, Etienne, Magdelaine and Jullien,...

concentration of proteins in Hemoce, whereas the others detected various concentrations in the solution. The Hemoce dilutions and the results obtained after processing these dilutions on different analyzers are shown in Fig. 1. Because Hemoce is itself a mixture of polypeptides, it is inaccurate to say that Hemoce positively interferes with some urine protein methods. Nevertheless, when determi...

Hereditary hemochromatosis (HH) is a prevalent human disease caused by a mutation in HFE, which encodes an atypical HLA class I protein involved in regulation of intestinal iron absorption. To gain insight into the pathogenesis of hemochromatosis, we have bred Hfe knockout mice to strains carrying other mutations that impair normal iron metabolism. Compound mutant mice lacking both Hfe and its ...