Complexes of copper (II) with hesperetin, naringenin, and apigenin of general composition [CuL(2)(H(2)O)(2)] nH(2)O (1-3) have been synthesized and characterized by elemental analysis, UV-Vis, FT-IR, ESI-MS, and TG-DTG thermal analysis. The free ligands and the metal complexes have been tested in vitro against human cancer cell lines hepatocellular carcinoma (HepG-2), gastric carcinomas (SGC-79...

The present manuscript reviews the findings of different research studies that evaluate use fungal solid-state (SSF) and submerged culture fermentation (SCF) with agro-industrial residues as substrates to enhance production polyphenols their possible uses food additives. Some (peels, pulps seeds) are an important source phenolic acids (p-coumaric, p-hydroxybenzoic, chlorogenic, cinnamic, feruli...

Objective: The purpose of this study was to determine the structural-based molecular interactions between flavonoids contained in Acalypha indica L. and caspase-3 by docking dynamics (MD) simulations.
 Methods: In a computer simulation, ten A. were evaluated for using X-ray crystal structure human (PDB ID 1NME). AutoDock 4.2 software used docking, MD simulations done with GROMACS v2018.&#x...

Untargeted metabolomics identified urinary biomarkers able to discriminate between the intake of fresh hand-squeezed and industrially processed orange juices. Processing led an upregulation in excretion hydroxy-polymethoxyflavone sulfates, abscisic acid, sinapic acid 4′-glucuronide. The demethylated polymethoxyflavone metabolites were produced with a significant interindividual variability sugg...