Covid-19 disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a global epidemic that affects millions of lives. To date, there no definitive cure for the and vaccination efforts with newly produced vaccines will take years to complete. In silico studies have suggested different flavonoids play an antiviral role against SARS-CoV-2. this study, based on in findings, w...

Coronavirus 2 (SARS-CoV-2) sebagai penyebab COVID-19 mengakibatkan sindrom pernafasan akut parah dengan sel yang ditargetkan; epitel hidung dan bronkus pneumosit. SARS-CoV-2 menggunakan tipe transmembran serine protease (TMPRSS2) media untuk membelahangiotensin converting enzyme receptor (ACE2) mengaktifkan protein SAR-CoV-2. ACE2 banyak ditemukan pada lidah. Lonjakan struktural virus (S) menun...

Cyclodextrin glycosyltransferase (CGTase) can catalyze the glycosylation of hesperidin, resulting in α-glycosyl hesperidin with significantly improved water solubility. In this study, a rational design CGTase to improve its activity was investigated. The strategy we employed involved docking near-attack conformation and virtually mutating surrounding residues, followed by calculating changes bi...

Storage of 42° Brix Pineapple and Valencia orange concentrates at 40° F. resulted in in creased gelation, clarification, and apparent pulp content, whereas pectin decreased. Total glycosides, as hesperidin, remained constant in these products during storage. The experi mental packs heated at 1and 2-fold were more stable than those heated at 3and 4fold; also all of the Valencia concentrates, con...

Orange juice represents one of the main orange fruit consumption worldwide, and during this process, about 50% fresh weight remains as by-products. These by-products comprise mainly peels pulps, known pomace, rich in bioactive compounds (BCs) such essential oils, phenolic (mainly hesperidin), pectin. BCs provide various health benefits, like antioxidant, anti-inflammatory, anti-microbial, anti-...

India is sitting on a gold mine of well-recorded and traditionally well practiced knowledge of herbal medicine. General phytochemical screening of Citrus sinensis (Orange) belonging Rutaceae family revealed the presence of flavones glycoside. The aim of this study is to identify and characterize the bioactive principle compound (Hesperidin) from the dried peel of C. sinensis fruit. It has wide ...