Heterocyclic compounds are numerous and diverse group of organic compounds. Heterocycles abundantly found in nature express various physiological properties. intricately linked to all aspects life. There many heterocyclic currently known, the number is constantly rising owing extensive synthetic development their applications. used significantly a areas, including biochemistry medicinal chemist...

Different novel isoxazolines were synthesized by the cyclization of secondary amino derivatives with pyridazine as a substituted intermediate in presence hydroxylamine hydrochloride. Isoxazoline is an important class nitrogen and oxygen-containing five-membered heterocyclic compounds having great medicinal importance. Many heterocyclic, pharmaceutically active have been using it intermediate. D...

A versatile protocol for the synthesis of azolium thioglycosides is reported. This based on a PdG3-catalyzed Migita cross-coupling between p-di-iodo azoliums and protected or unprotected β-1-thioglucose partners. Moreover, solvent-free mechanochemistry approach was developed as unique access to corresponding Ag(I)-N-heterocyclic carbene thioglycosides. Finally, chemical reactivity antiprolifera...

A series of heterocyclic acene diimides were synthesized effectively based on the condensation of o-phenylenediamine, 1,2-benzenedithiol, and 2-aminothiophenol with 2,3,6,7-tetrabromo-1,4,5,8-naphthalene tetracarboxylic diimide. The diimides exhibit interesting optical and electrical properties with one of them showing a hole mobility up to 0.02 cm(2) V(-1) s(-1).

Heterocyclic amines (HAs) occur at the ppb range in foods. Most of them demonstrate potent mutagenicity in bacteria mutagenicity test, and some of them have been classified by the International Agency for Research on Cancer as probable/possible human carcinogens. Their capability of formation even during ordinary cooking practices implies frequent exposure by the general public. Over the past 3...

The N-heterocyclic carbene (NHC)-organocatalyzed enantioselective annulation reaction of pyrazolones with α,β-unsaturated aldehydes proceeding via the chiral α,β-unsaturated acyl azolium intermediates under oxidative conditions is presented. The reaction afforded dihydropyranone-fused pyrazoles in moderate to good yields and good er values under operationally simple and base-free conditions.

3-Amino-5-(4-chlorophenylamino)-4-cyanofuran-2-carboxamide (2) was used as the key molecule for preparation of various furopyrimidines 3-9 and formation of spiro-cycloalkane furopyrimidines 10, 11. Also, poly fused heterocyclic compounds 13-17 were prepared from compound 2. The synthesized compounds were screened for their antimicrobial activity.

 Caffeic acid phenethyl ester(CAPE) suppresses the growth of transformed cells such as human breast cancer cells, hepatocarcinoma , myeloid leukemia, colorectal cancer cells, fibrosarcoma, glioma and melanoma. A group of heterocyclic esters of caffeic acid was synthesized using Mitsunobu reaction and the esters were subjected to further structural modification by electrooxidation of the catecho...

The heterocyclic analogs of o-quinodimethane (OQDM, o-xylylene) are of considerable interest both from a theoretical point of view and for their potential in organic synthesis 1 as useful dienes. This has been elegantly demonstrated in the indole series 2 for the synthesis of several naturally occurring and biologically important indole 3 and carbazole 4 alkaloids. However, with the exception o...

Most of the organic compounds applied as pharmaceuticals or intermediates utilized in their synthesis contain heterocyclic motifs [...]