objectives: to generate synthesized information on the epidemiology of vzv infection, as well as an estimation of prevalence of age-specific antibody in iranian less than 40. material and methods: after exclusion of irrelevant and overlapping reports, 15 papers were included (from nine major cities). studies were pooled according to the heterogeneity test results. random effect model methods we...

Background Gray zone or infarct heterogeneity, defined as the admixture of necrotic and viable myocardium at the periphery of myocardial infarction (MI), has been noted to be a modulator of cardiac outcomes. Most studies have not reported a direct correlation between infarct core and the zone of heterogeneity. Furthermore, no large population based studies have examined the burden of undiagnose...

Tumor evolution from a single cell into malignant tissue comprised of diverse populations remains poorly understood. We profiled transcriptomes genetically engineered mouse lung tumors at eight stages spanning tumor progression atypical adenomatous hyperplasia to adenocarcinoma. The diversity transcriptional states spanned by cells increased over time and was reproducible across mice, but not e...

We study discrete panel data methods where unobserved heterogeneity is revealed in a first step, environments population not discrete. focus on two?step grouped fixed?effects (GFE) estimators, individuals are classified into groups using kmeans clustering, and the model then estimated allowing for group?specific heterogeneity. Our framework relies two key properties: function—possibly nonlinear...