Mitogen-activated protein kinase (MAPK) p38 is activated in response to stress stimuli and growth factors relevant to the pathogenesis of diabetic nephropathy. We postulated that mesangial cells exposed to high glucose and to endothelin-1 (ET-1), angiotensin II (ANG II), and platelet-derived growth factor (PDGF) demonstrate enhanced p38 activity and subsequent activation of the cAMP responsive ...

In the title compound, [Hg(C(42)H(38)N(4)O(2))](PF(6))(2)·2CH(3)CN, the Hg(II) cation lies on a twofold axis which is also the inter-nal symmetry element of the complete cationic complex. The Hg(II) cation is coordinated by two symmetry-related C(carbene) atoms [Hg-C = 2.058 (9) Å] in a nearly linear geometry, with a C-Hg-C angle of 175.8 (5)°. There are weak inter-molecular C-H⋯F inter-actions...

Long-standing diabetes can result in the development of cardiomyopathy, which can be accompanied by myocardial fibrosis. Although exposure of cultured kidney and skin fibroblasts to high glucose (HG) concentration is known to increase collagen synthesis, little is known about cardiac fibroblasts (CFs). Therefore, we determined the influence of HG conditions on CF functions and the effects of lo...

The use of calixpyrroles as cation monitoring systems is very limited. The importance of fundamental studies for providing the basis for the selection of an appropriate ionophore for use in the design of ion selective electrodes cannot be overemphasised. Thus a new ditopic receptor, namely meso-tetramethyltetrakis-(4N,N-diethylacetamide) phenoxymethyl]calix[4]pyrrole (CPA), bearing cation and a...

The Tibetan Plateau (TP), known as the "Third Pole", is a critical zone for atmospheric mercury (Hg) deposition. Increasing anthropogenic activities in the globe leads to environmental changes, which may affect the loading, transport and deposition of Hg in the environment. However, the deposition history and geochemical cycling of Hg in the TP is still uncertain. Our records of Hg and Hg isoto...

The present work investigated the effect of surface oxygenated groups on the adsorption of Cd(II) and Hg(II) by activated carbon. A study was undertaken to determine the adsorption isotherms and the influence of the pH on the adsorption of each metallic ion by a series of ozonized activated carbons. In the case of Cd(II), the adsorption capacity and the affinity of the adsorbent augmented with ...

Ratiometric fluorescent chemosensors 1 and 2 were synthesized based on tyrosine amino acid derivatives with a pyrene fluorophore. 1 and 2 showed high selectivity for Hg(II) ions among 13 metal ions in aqueous solutions. Both 1 and 2 sensitively detected Hg(II) ions in aqueous solutions by ratiometric response without interference of any of the other tested metal ions including Cu(II), Cd(II), P...

The formation of complexes of Zn(II), Cd(II), Hg(II), and Pb(II) and N -carboxymethylD,L-threonine (H2CMT, H2L) in aqueous solutions has been studied by spectrophotometric and potentiometric methods. The complexation model for each system has been established by the HYPERQUAD program from the potentiometric data. Three different behaviors are found: ML2H, MLH, ML, MLOH, and ML2 complexes are fo...