PURPOSE To determine if pulsed-high intensity focused ultrasound (HIFU) could effectively serve as a source of hyperthermia with thermosensitive liposomes to enhance delivery and efficacy of doxorubicin in tumors. EXPERIMENTAL DESIGN Comparisons in vitro and in vivo were carried out between non-thermosensitive liposomes (NTSL) and low temperature-sensitive liposomes (LTSL). Liposomes were inc...

Efficient and noninvasive generation of cavitation bubbles in soft tissue is a challenging task due to the lack of cavitation nuclei (i.e., pre-existing gas bubbles). In this study, we present a method to generate and enhance cavitation activity based on the utilization of two consecutive ultrasound waves at different frequencies. First, a high frequency (5 MHz) high intensity focused ultrasoun...

Objective To investigate the clinical effect of high intensity focused ultrasound (HIFU) ablation combined with gonadotropin-releasing hormone agonist (GnRH-a) and levonorgestrel-releasing intrauterine system (LNG-IUS) in treatment adenomyosis patients who failed to respond drug therapies.Study design A total 47 had therapies no fertility desires were treated HIFU GnRH-a LNG-IUS. The score dysm...

Background/introduction Unilateral lung flooding replaces air with saline in lung parenchyma. It has been shown, that in flooded condition ultrasound guidance and HIFU ablation of central lung cancer tissue is feasible. The flooding process generates a saline-lung compound which is different than known parenchymal tissue. Complete understanding of the flooding process is essential for its imple...

Magnetic resonance (MR)-high-intensity focused ultrasound (HIFU) is an innovative, noninvasive tumour ablation technique. MR imaging and focused ultrasound are combined allowing real-time anatomic guidance and temperature mapping during treatment. Recently, the volumetric ablation approach has been introduced in order to reduce treatment length and provide more homogeneous tumour ablation. Afte...

OBJECTIVES To determine the incidence and magnitude of the rapid increase in the serum PSA (riPSA) level after high-intensity focused ultrasound (HIFU) therapy for prostate cancer, and its correlation with clinical factors. METHODS A total of 176 patients with localized prostate cancer underwent HIFU therapy. Serum riPSA was determined on the basis of the same criteria as those for "PSA bounc...

In this paper, we report on a study that investigated the feasibility of reliably visualizing high-intensity focused ultrasound (HIFU) lesion boundaries using axial-shear strain elastograms (ASSE). The HIFU-induced lesion cases used in the present work were selected from data acquired in a previous study. The samples consisted of excised canine livers with thermal lesions produced by a magnetic...

Methods Material and method: Focal One is a device designed for the focal therapy of Prostate Cancer combing the necessary tools to visualize, target, treat and validate the focal treatment. MR volumes are imported through the hospital’s network. The operator defines the contours of the prostate and the regions of interests that have been confirmed as prostate tumors. The same contouring of the...

BACKGROUND High-intensity focused ultrasound (HIFU) is an emerging treatment for select patients with localized prostate cancer (PCa). OBJECTIVES To report the oncologic outcome of HIFU as a primary care option for localized prostate cancer from a multicenter database. DESIGN, SETTING, AND PARTICIPANTS Patients with localized PCa treated with curative intent and presenting at least a 2-yr f...

Basic research and clinical applications of HIFU to treat many life-threatening diseases such as uterine fibroids, osteosarcoma, liver cancer, breast cancer, and many others have attracted broad interests in global medical communities (Nat Rev Cancer. 2005; 5(4): 321-327; Nature Reviews Drug Discovery. 2005; 4:255-260). HIFU has been considered as one of the most important developing technologi...