To increase the effectiveness of high intensity focused ultrasound (HIFU) treatments, prediction of ultrasound propagation in biological tissues is essential, particularly where bones are present in the field. This requires complex full-wave computational models which account for nonlinearity, absorption, and heterogeneity. These models must be properly validated but there is a lack of analytic...

Hepatocellular carcinoma (HCC) is one of the most common cancers in the world. High intensity focused ultrasound (HIFU) plays an important role in treatment of HCC. HIFU has two methods in tumor treatment, which have thermal and mechanical effects. The absorption of ultrasound energy causes a rise in temperature at the target point of the tumor. Although necrosis occurs, tissue located near the...

Intra-procedural imaging is important for guiding cardiac arrhythmia ablation. It is difficult to obtain intra-procedural correlation of thermal lesion formation with action potential (AP) changes in the transmural plane during ablation. This study tested parametric ultrasound imaging for transmural imaging of lesion and AP changes in high intensity focused ultrasound (HIFU) ablation using coro...

Beauty treatment for skin requires a high-intensity focused ultrasound (HIFU) transducer to generate coagulative necrosis in a small focal volume (e.g., 1 mm³) placed at a shallow depth (3-4.5 mm from the skin surface). For this, it is desirable to make the F-number as small as possible under the largest possible aperture in order to generate ultrasound energy high enough to induce tissue coagu...

Materials and method 110 leiomyomas in 98 women (average age 39,3 years) were treated with MRI-guided focused ultrasound (MRgFUS). The treatment is carried out using the ablative properties of the HIFU system under 3T MRI guide. Symptoms (e.g. menorrhagia, pelvic pain) were scored using Severity Score (SS) and quality of life was determined using the UFS-QOL score. Pre-treatment measurementes o...

Background A majority of patients (85-90%) diagnosed with pancreatic cancer has advanced disease at the time of diagnosis with a dismal prognosis. Pain is a common symptom in patients (60-90%) with advanced disease. Pain is neuropathic and inflammatory, resulting from both tumour expansion and tumour invasion of the celiac and mesenteric plexus. Opioids have side effects and may not be sufficie...

High-intensity focused ultrasound (HIFU) has been emerging as an effective and noninvasive modality in cancer treatment with very promising clinical results. However, a small vessel in the focal region could be ruptured, which is an important concern for the safety of HIFU ablation. In this study, lesion formation in the polyacrylamide gel phantom embedded with different tubing (inner diameters...