The anti-malarial drug artemisinin, produced naturally in the plant Artemisia annua, experiences unstable and insufficient supply as its production relies heavily on source. To meet massive demand for this compound, metabolic engineering of microbes has been studied extensively. In study, we focus improving amorphadiene, a crucial artemisinin precursor, Bacillus subtilis. expression level plant...

In a high level synthesis environment there is a strong need for flexible module generators. For the generation of regular structures efficient dedicated module generators can be built. This paper describes the structure of a ’block– multiplier’, which features a wide range of area–time tradeoffs maintaining efficiency. The structure makes it possible to implement a fully serial or a fully para...

| This paper describes a novel approach to high-level synthesis of arbitrarily complex pipelined circuits, including pipelined circuits with feedback, and the synthesis algorithm that makes the approach viable in practice. Our approach provides a high-level, modular speciication language with an eecient implementation. In our system, the designer speciies the circuit as a set of independent mod...

T/ie paper describes objcctives of high-level synthesis. It concentrates on operation scheduling strategies and thc interaction with the resource allocation. Some transformational and iterative/constructive scheduling algorithms are described. Moreover, a new scheduling/alhcation approach is prcsented and compared with other known algorithms. Finally, some open problems of the high-levcl synthe...