Ehlers-Danlos syndrome is an inherited heterogeneous group of connective tissue disorders, characterized by abnormal collagen synthesis, affecting skin, ligaments, joints, blood vessels and other organs. It is one of the oldest known causes of bruising and bleeding and was first described by Hipprocrates in 400 BC. Edvard Ehlers, in 1901, recognized the condition as a distinct entity. In 1908, ...

In the recent years, interstitial brachytherapy implantation has become the treatment of choice for early stage prostate cancer patients (1, 2, 3). Popularity of this modality is most likely due to the fact that five-and ten-year disease control rates of brachytherapy are equal to those of the surgical and external radiation therapy, whereas, the toxicity and side-effects are perceived to be lo...

The purpose of this report is to present a short review of the history of Wilson’s disease and to describe the first diagnosed case at the Neurologic Clinic of Hospital das Clínicas of São Paulo University Medical School. The topics of the historical review are the first contributions of authors along the second half of the XIX century, the seminal monograph of Samuel Alexander Kinnier Wilson (...

Purinergic signalling is now recognized to be involved in a wide range of activities of the nervous system, including neuroprotection, central control of autonomic functions, neural-glial interactions, control of vessel tone and angiogenesis, pain and mechanosensory transduction and the physiology of the special senses. In this article, I give a personal retrospective of the discovery of purine...

In current-day medicine, endoscopy plays an important role in the diagnosis and treatment of many different conditions. This improving technology has led to new areas of endoscopic visualization, particularly of the epidural space, spinal cord and contiguous structures. A review of the medical literature indicates that clinicians have been working with various types of endoscopes for over sixty...

of knowledge, such as Colles' fracture, which every medical student is eventually called upon to recite. The dissecting guide is illustrated with 79 plates, which might well be somewhat larger, in black and white. The type is large and clear with major points emphasized in black, heavy type, thus facilitating review and minimizing the need for underlining. The book is bound so that it lies flat...

The study of human skeletal remains from archaeological sites gives us the opportunity to answer important questions about the lifestyle of past populations. The discipline that studies human skeletal remains is known as bioarchaeology. This paper provides a historical review of bioarchaeological research in Croatia. It is based on the available published material that analyzes human skeletal r...

Insulin is the most effective blood glucose lowering agent and remains one of the cornerstones of diabetes management. However, many individuals with diabetes are either reluctant to initiate or are nonadherent to their insulin therapy for various reasons, including fear of frequent injections. Technosphere Insulin (TI) is a novel inhaled insulin powder that is approved by the United States Foo...

Sperm DNA Fragmentation has been extensively studied for more than a decade. In the 1940s the uniqueness of the spermatozoa protein complex which stabilizes the DNA was discovered. In the fifties and sixties, the association between unstable chromatin structure and subfertility was investigated. In the seventies, the impact of induced DNA damage was investigated. In the 1980s the concept of spe...

By reading, you can know the knowledge and things more, not only about what you get from people to people. Book will be more trusted. As this biological warfare and bioterrorism a historical review, it will really give you the good idea to be successful. It is not only for you to be success in certain life you can be successful in everything. The success can be started by knowing the basic know...