Mutations can interfere with posttranscriptional expression of the HLA-A and -B genes. B-lymphoblastoid cells that contain one copy of the major histocompatibility complex (MHC) were subjected to mutagenesis and immunoselection for MHC antigen-loss mutants. Some mutations partially reduced surface expression of HLA-A and eliminated HLA-B expression concurrently, although the HLA-A and -B genes ...

PURPOSE Because the expression of human leukocyte antigen (HLA) antigens is important for immunologic recognition of tumor cells, we determined expression of locus-specific HLA class I antigens in uveal melanoma and tested whether the level of HLA expression was related to prognosis or associated with known prognostic parameters. METHODS Expression of HLA-A and -B antigens was determined on 3...

BACKGROUND Chronic allograft rejection manifested as bronchiolitis obliterans syndrome (BOS) is the leading cause of late death after lung transplantation. Although increasing evidence suggests an association between anti-human leukocyte antigens (HLA) antibodies and chronic rejection of kidney or heart allografts, the clinical significance of anti-HLA antibodies in lung recipients is less clea...

Ulcerative colitis (UC) is a nonspecific acute and chronic inflammatory bowel disease that diffusely involves the colonic mucosa. The etiology of UC has not yet been elucidated fully. However, many studies have found that immunologic disorders may play a role in the pathogenesis of UC. In addition, due to an increased frequency of UC in families, especially an increased monozygotic compared...

Fifty consecutive patients with migraine headaches were evaluated for the presence of 10 HLA-A and 14 HLA-B antigens by means of the microlymphocytotoxicity assay. Comparisons were made between classical and common migraine, and between patients with and without a family history of migraine. All groups of patients showed an association with B8 and B27, which failed to reach clinical significanc...

The clinical impact of non-HLA specific antibodies either alone or in concert with donor HLA specific antibodies (DSA) has been an intense area of research in kidney transplantation and more recently in thoracic transplantation as well. These non-HLA antigens include receptors expressed by the vascular endothelium such as the G protein coupled receptors (GPCRs), Major Histocompatibility Complex...

The non-classical human leukocyte antigen (HLA) class Ib genes, HLA-E, -G and -F, are located on chromosome 6 in the human major histocompatibility complex (MHC). HLA class Ib antigens resemble the HLA class Ia antigens in many ways, but several major differences have been described. This review will, in particular, discuss HLA-G and its role in human reproduction and in the human MHC. HLA-G se...

Natural killer (NK) cells kill normal and transformed hematopoietic cells that lack expression of major histocompatibility complex (MHC) class I antigens. Lysis of HLA-negative Epstein Barr virus-transformed B lymphoblastoid call lines (B-LCL) by human NK cell clones can be inhibited by transfection of the target cells with certain HLA-A, -I3, or -C alleles. NK cell clones established from an i...

Cytotoxic T lymphocytes, induced by stimulating the PBMC of an HLA-B27+ normal individual (B27+, AS-) with the PBMC of an HLA-identical sibling suffering from ankylosing spondylitis (AS) (B27+, AS+), specifically lyse B27+, AS+ PBMC but not PBMC from HLA-27+ or B27-, AS- normal controls, or from HLA-B27- AS patients (B27-,AS+). CTL of similar specificity can also be raised by immunizing in vitr...

Cross-reactions between mammalian transplantation antigens and certain bacterial structures have been postulated on the basis of various observations. In a series of convincing experiments, Rapaport and Chase (1-3) have clearly demonstrated that skin graft sensitization may be achieved with streptococcal membrane antigens in a variety of different species, such as guinea pigs, mice, rats, or ra...