Despite recent advances, there remains a need to improve treatment options and survival outcomes for patients with hematological malignancies. Considerable research is ongoing develop advanced therapy medicinal products (ATMPs) in this disease area. Some ATMPs have already received regulatory apprvoal the number of therapeutic range indications approved will probably increase coming years. Rese...

Aim: We describe an atypical case of central nervous system (CNS) involvement in non-Hodgkins lymphoma (NHL), presenting with ocular manifestations. Presentation: Here we present an extremely rare case of a 63 year old male with past history of relapsed NHL in remission with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone) chemotherapy, primarily presenting with bil...

This study aimed to assess the efficacy of a multimodality imaging approach for differentiating between primary extranodal non-Hodgkin's lymphoma (NHL) and squamous cell carcinoma (SCC) of the maxillary sinus. Twelve NHLs and 29 SCCs of the maxillary sinus were included. CT findings, MR signal intensities, apparent diffusion coefficients (ADCs), and maximum standardized uptake values (SUVmax) w...

DESCRIPTION A 47-year-old unemployed man presented with a 2-week history of shortness of breath, dry cough and fever despite normal inflammatory markers and negative blood cultures. There was no weight loss or night sweats. He was a non-smoker and had no other medical history. HIV testing and tumour markers were negative. Chest x-ray (figure 1A) showed what seemed to be a dense consolidation in...

Although the success of trastuzumab and rituximab for treatment of breast cancer and non-Hodgkins lymphoma, respectively, suggests that monoclonal antibodies (mAbs) will become important therapeutic agents against a wider range of cancers, useful therapeutic Abs are not yet available for the majority of the human cancers because of our lack of knowledge of which antigens (Ags) are likely to bec...

CONTEXT Primary central nervous system lymphomas (PCNSL) are a rare subgroup of lymphomas generally associated with HIV and EBV. OBJECTIVE To study ten autopsy cases of PCNSL, to describe the neuropathological findings, to characterize the phenotype of the neoplastic cells, to detect EBV in the lesion and to compare the findings with the clinical and laboratory data of the patients. METHOD ...

general immunological disturbance is one of the questions considered in this book, but not fully answerable as yet. There are two ways in which a review of this kind might be written, one comprehensively with a maximum of sources cited and a minimum of personal bias interjected, the other analytically with sources selected and interpreted in the light of the author's opinions. Fraser and Martin...

Ischaemic colitis (IC) is a dangerous condition usually caused by atherosclerosis and low blood flow states w1x. Haemodialysis (HD) patients are at increased risk of IC because they have accelerated rates of arterial vascular disease w2x and because hypotension is common during dialysis with large amounts of fluid removal. Thus, IC in the HD patient is usually attributed to atherosclerotic orig...