Following a study of the existing algorithms for image-based homing, and their strengths and weaknesses, a new, adaptive controller was designed. The controller achieves homing through gradient descent of the RMS surface by modelling C. Elegans chemotaxis with a first-order function. The controller parameters were evolved in a simulated environment, and were then tested and evaluated both in si...

The homing endonuclease I-CreI recognizes and cleaves a particular 22 bp DNA sequence. The crystal structure of I-CreI bound to homing site DNA has previously been determined, leading to a number of predictions about specific protein-DNA contacts. We test these predictions by analyzing a set of endonuclease mutants and a complementary set of homing site mutants. We find evidence that all struct...

Stem cell homing into the bone microenvironment is the first step in the initiation of marrow-derived blood cells. It is reported that human severe combined immunodeficient (SCID) repopulating cells home and accumulate rapidly, within a few hours, in the bone marrow and spleen of immunodeficient mice previously conditioned with total body irradiation. Primitive CD34(+)CD38(-/low)CXCR4(+) cells ...

The beta 7-integrin subunit can pair with two alpha-chains, alpha 4 and alpha E, and is expressed mainly on lymphocytes. As an alpha 4-heterodimer it binds to the mucosal addressin MAdCAM-1, thus acting as a mucosal homing receptor. As an alpha E-heterodimer it binds to E-cadherin and is mainly found on intestinal intraepithelial lymphocytes. Consequently, beta 7 is mostly expressed on lymphocy...

Stream Control Transmission Protocol (SCTP) is the third transport layer protocol next to TCP and UDP. The SCTP provides some distinctive features over the TCP. This paper is purposed to compare SCTP and TCP in the performance perspective. We compare the throughput of SCTP and TCP for the three different test scenarios: the performance comparison of SCTP and TCP for the different size of the us...

This study illustrates how obstacle avoidance can emerge from a visual homing strategy, caused by the intrinsic geometric structure of the environment. An example is shown where an agent performs visual homing in a virtual environment with several obstacles which also serve as visual landmarks. The agent has omnidirectional vision similar to many prey animals. The applied visual homing strategy...

Background/introduction Maximal homing of iv-infused MSC may be critical for cell therapies. Molecular responses from the primarily mechanical effects of pulsed focused ultrasound (pFUS) (i.e., mechanotransduction) in healthy or diseased murine kidneys generate a “molecular zip-code” consisting of local increases in chemoattractants (cytokines, chemokines, cell adhesion molecules) to enhance MS...

{ Homing sequences play an important role in the testing of nite state systems and have been recently used in learning algorithms due to Rivest and Schapire 17] and Freund et al. 4]. It is well-known that every minimal DFA has a homing sequence of length O(n 2) which can be constructed sequentially in time O(n 3). But no eecient parallel algorithm was known for this problem. In this work, we pr...

T cells are imprinted to express tissue-specific homing receptors upon activation in tissue-draining lymph nodes, resulting in their migration to the site of Ag entry. Expression of gut-homing molecules alpha(4)beta(7) and CCR9 is induced by retinoic acid, a vitamin A metabolite produced by retinal dehydrogenases, which are specifically expressed in dendritic cells as well as stromal cells in m...