BACKGROUND The accurate and precise measurement of urinary albumin is critical, since even minor increases are diagnostically sensitive indicators of renal disease, cardiovascular events, and risk for death. To gain insights into potential measurement biases, we systematically compared urine albumin measurements performed by LC-MS, a clinically available immunoturbidimetric assay, and size-excl...

The concentration of carotenoids and fat-soluble vitamins in human plasma may play a significant role in numerous chronic diseases such as age-related macular degeneration and some types of cancer. Although these compounds are of utmost interest for human health, methods for their simultaneous determination are scarce. A new high pressure liquid chromatography (HPLC)-tandem mass spectrometry (M...

The hydrogenation of 4-nitrophenol (4-NP) has attracted much attention, since it is typically used as a model reaction for evaluating newly developed catalysts, but its mechanism still debated. Herein, Co(OH)2-modified CuO catalyst (Co(OH)2/CuO) was the reduction 4-NP to 4-aminophenol (4-AP) in an aqueous sodium borohydride (NaBH4) solution. investigated by UV-Vis spectroscopy (UV-Vis), high-pe...

BACKGROUND Posaconazole is a novel antifungal drug for oral application intended especially for therapy of invasive mycoses. Due to variable gastrointestinal absorption, adverse side effects, and suspected drug-drug interactions, therapeutic drug monitoring (TDM) of posaconazole is recommended. METHOD A fast ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method ...

Paracetamol (Acetaminophen) is one of the drugs most often prescribed to patients, ranging from children elderly, as a pain reliever by inhibiting prostaglandin synthesis in central nervous system. has broad therapeutic index with an adult dose 500-1000 mg each time, interval 4-6 hours. The review article aims compare analysis and sample preparation methods used detect paracetamol human blood, ...