نتایج جستجو برای: hsa mir 490 5p
تعداد نتایج: 54056 فیلتر نتایج به سال:
Subtypes of renal tumors have different genetic backgrounds, prognoses, and responses to surgical and medical treatment, and their differential diagnosis is a frequent challenge for pathologists. New biomarkers can help improve the diagnosis and hence the management of renal cancer patients. We extracted RNA from 71 formalin-fixed paraffin-embedded (FFPE) renal tumor samples and measured expres...
PURPOSE Recent studies have suggested that microRNA biomarkers could be useful for stratifying lung cancer subtypes, but microRNA signatures varied between different populations. Squamous cell carcinoma (SCC) is one major subtype of lung cancer that urgently needs biomarkers to aid patient management. Here, we undertook the first comprehensive investigation on microRNA in Chinese SCC patients. ...
BACKGROUND We have previously shown that hsa-miR-520d-5p can convert cancer cells into induced pluripotent stem cells (iPSCs) or mesenchymal stem cells (MSCs) via a dedifferentiation by a demethylation mechanism. METHODS We tested the effect of miR-520d-5p on human fibroblasts to determine whether it could be safely used in normal cells for future clinical therapeutic applications. After we t...
Abstract Background Left ventricular remodeling (LVR) in patients with ST-segment elevation myocardial infarction (STEMI) may lead to poor prognosis which circulating exosome miRNAs play a critical role. The aim of the present study is identify specific for LVR STEMI. Method Plasma were assessed 20 (90% male, mean age 66.95±1.65 years) 3–6 months after STEMI and 24 healthy individuals (83% 33.2...
Invasive lobular carcinoma (ILC) of the breast, characterized by loss of E-cadherin expression, accounts for 5-15% of invasive breast cancers and it is believed to arise via a linear histological progression. Genomic studies have identified a clonal relationship between ILC and concurrent lobular carcinoma in situ (LCIS) lesions, suggesting that LCIS may be a precursor lesion. It has been shown...
BACKGROUND Osteoarthritis (OA) is a multifactorial disease characterized by destruction of the articular cartilage due to environmental, mechanical and genetic components. The genetics of OA is complex and is not completely understood. Recent works have demonstrated the importance of microRNAs (miRNAs) in cartilage function. MiRNAs are a class of small noncoding RNAs that regulate gene expressi...
چکیده: سرطان معده یکی از علل مرگ ومیر در جهان و به خصوص در کشورهای آسیایی می باشد. میکرو rna ها،rna های کوچک غیر کد کننده به طول 20-24 نوکلئوتید هستند که در تنظیم بیان ژن بعد از رونویسی نقش دارند. میکرو rna ها قادر به اتصال به ناحیه ترجمه نشدنی 3 ژن هدف هستند. این اتصال سبب تخریب mrna یا مهار ترجمه می شود. میکرو rna های بسیاری تاکنون در سلول های انسانی شناسایی شده است که در مراحل مختلف رشد و نم...
Recent studies have indicated that long non-coding RNAs (lncRNAs) and mRNA function as competing endogenous RNAs (ceRNAs) that compete to bind to shared microRNA (miRNA) recognition elements (MREs) to perform specific biological functions during tumorigenesis. The tumor suppressor p53 is a master regulator of cancer-related biological processes by acting as a transcription factor to regulate ta...
Quantitative real-time PCR (qPCR) is the most frequently used method for measuring expression levels of microRNAs (miRNAs), which is based on normalization to endogenous references. Although circulating miRNAs have been regarded as potential non-invasive biomarker of disease, no study has been performed so far on reference miRNAs for normalization in colorectal cancer. In this study we tried to...
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