We investigated effects of endostatin (ES) in the prometastatic microenvironment of inflammation occurring during the microvascular phase of cancer cell infiltration in the liver. We used a model of intrasplenic injection of B16 melanoma (B16M) cells leading to hepatic metastasis through vascular cell adhesion molecule-(VCAM-1)-mediated capillary arrest of cancer cells via interleukin-18 (IL-18...

An audit was undertaken in 2009 to determine the success of the new national orthodontic referral protocol introduced to the Health Service Executive (HSE) in 2007 and operated in the Dublin Mid-Leinster HSE region. It was repeated in 2011 to determine if the HSE austerity measures have had a bearing on the orthodontic service performance in the Dublin Mid-Leinster HSE region. The audit also me...

Abstract The current research explores the transformative potential of Design Thinking (DT) pedagogy in Higher Sustainability Education (HSE) a hybrid (mix online and face-to-face) setting. case study examined Field Exercise Science (FESS) course, using DT pedagogy, HSE program at university Japan. critical learning experiences (i.e., signs learning) were captured to investigate whether has all...

Abstract Background The Health & Safety Executive Indicator Tool (HSE-IT) is a standard-based questionnaire commonly used to assess work-related stress in organizations. Although the HSE-IT validity has been well documented and significant relationships have observed between its scales several outcomes, date there no evidence concerning burnout among healthcare workers. Aims To investigate ...

OBJECTIVE To characterize clinical features, neuroimaging, and outcomes of herpes simplex encephalitis (HSE) in immunocompromised individuals. METHODS We performed a retrospective case control review of patients diagnosed with HSE. Adult patients were dichotomized into immunocompromised (n = 14) and immunocompetent groups (n = 15). RESULTS Fewer immunocompromised patients presented with pro...

BACKGROUND AND PURPOSE Herpes simplex encephalitis (HSE) is the most common type of sporadic encephalitis worldwide, and it remains fatal even when optimal antiviral therapy is applied. There is only a weak consensus on the clinical outcomes and prognostic factors in patients with HSE. This study examined whether the radiological and electrophysiological findings have a prognostic value in pati...

OBJECTIVE To elucidate the value of early computed tomographic (CT) signs of stroke in predicting the occlusion site in the cerebral arteries. PATIENTS 105 consecutive patients with acute embolic stroke affecting the anterior circulation. METHODS Four early signs were evaluated on cranial CT within six hours of stroke onset: loss of the insular ribbon (LIR); attenuation of the lentiform nuc...

The DNA-binding and transcriptional activities of the heat shock transcription factor 1 (HSF1) are repressed under normal conditions and rapidly upregulated by heat stress. Here, we tested for the ability of various stress agents to activate HSF1 in the Xenopus oocyte model system. The HSE-binding activity of HSF1 was induced by a number of chemical stresses including cadmium, aluminum, iron, m...

Background: This study aimed to provide a comprehensive tool for the economic evaluation of investments in health, safety, and environment (HSE). Methods: developmental cross-sectional was conducted on costs benefits HSE combined cycle power plant Gilan province, 2021. The components preventive measure (PMCs) occupational accidents, diseases, environmental pollution (ADPCs) were determined by a...

INTRODUCTION Herpes simplex encephalitis (HSE) is a rare disease with a poor prognosis. No recent evaluation of hospital incidence, acute mortality and morbidity is available. In particular, decompressive craniectomy has rarely been proposed in cases of life-threatening HSE with temporal herniation, in the absence of evidence. This study aimed to assess the hospital incidence and mortality of H...