775 Reperfusion after stroke sonothrombolysis with microbubbles may predict intracranial bleeding L. Dinia, M. Rubiera, M. Ribo, O. Maisterra, G. Ortega, M. del Sette, J. Alvarez-Sabin, and C.A. Molina 781 Neurologic abnormalities in HTLV-I– and HTLV-II–infected individuals without overt myelopathy H.H. Biswas, J.W. Engstrom, Z. Kaidarova, G. Garratty, J.W. Gibble, B.H. Newman, J.W. Smith, A. Z...

Peripheral blood mononuclear cells (PBMCs) and T-cell lines from patients with Sezary syndrome (SS) and skin lesions from patients with mycosis fungoides (MF) were examined by polymerase chain reaction (PCR) for DNA sequences homologous to the human retroviruses human T-lymphotropic virus (HTLV)-I and -II. Results obtained using primers and probes from the tax/rex region of HTLV-I indicate that...


 Introducción: La paraparesia espástica es una infección causada por el virus linfotrópico de células T humanas (HTLV-1). Se caracteriza mielopatía lenta instauración que compromete principalmente los miembros inferiores. Afecta más a mujeres varones y las principales vías transmisión son: sanguínea, sexual vertical (principalmente durante la lactancia).
 Presentación del caso: Gesta...

The city of Salvador has the highest prevalence of HTLV-I among blood donors in Brazil. To study the prevalence of HTLV-I among the general population of Salvador, 30 “sentinel surveillance areas” were selected for the investigation of various infectious diseases, and 1385 individuals within these areas were surveyed according to a simple random sample procedure. ELISA was used to screen plasma...

The human T-cell leukemia virus type I (HTLV-I) and HTLVII Tax proteins are potent transactivators of viral and cellular gene expression. Using deletion mutants, the downstream parathyroid hormone-related protein (PTHrP) promoter is shown to be responsive to both HTLV-I and HTLV-II Tax as well as the AP1 /c-jun proto-oncogene. Transactivation of PTHrP by Tax was seen in T cells but not in B-cel...

The nucleotide sequence of the human T-cell leukemia virus type II (HTLV-II) long terminal repeat (LTR) and its surrounding regions were determined. Our results show the following structural features: (i) the LTR is 763 base pairs (bp) in length and consists of 314 +/- 1 bp of region U3, 248 +/- 1 bp of region R, and 201 bp of region U5; (ii) the terminal nucleotides in the LTR form an inverted...

The human T-cell leukemia virus type 2 (HTLV-2), an oncogenic retrovirus closely related to HTLV-1, produces a lifelong infection whose possible association to certain human diseases is still debated. Although some viral products can influence the expression and action of cellular genes, very little is known about the molecular mechanisms involved. Here we show that the AIR-1-encoded human majo...

PURPOSE We conducted a longitudinal analysis of human T lymphotropic virus type I (HTLV-I) viral markers in 28 Jamaican mothers and their children, who were monitored for a median of 6.2 years after the birth of the children. METHODS The HTLV-I provirus DNA load was measured using the Taqman system (PE Applied Biosystems). The HTLV-I antibody titer was determined using the Vironstika HTLV-I/I...

background: human t cell lymphotropic virus type i (htlv-i)-associated myelopa-thy/tropical spastic paraparesis (ham/tsp) is an inflammatory disease which occurs in less than 2% of htlv-i -infected individuals. high proviral load, high htlv-i-specific cd8+ cytotoxic t lymphocyte frequency (ctl) and host genetic factors such as hla all appear to be associated with htlv-i infection. previous stud...