Purpose: Surgical removal of solid primary tumors is an essential component of cancer treatment. Surgery-induced dysfunction innatural killer (NK) cells has been linked to the development ofmetastases in animalmodels andpatientswith cancer.We investigated the activationofNKcells using influenza vaccine in the perioperative period to eradicate micrometastatic disease. ExperimentalDesign:Both the...

Background: Influenza vaccines based on conserved proteins are being developed persistently. The conserved protein vaccines based on Nucleoprotein (NP) are highly protected vaccines against influenza viruses that can be used as a Universal vaccine. Aluminum hydroxide (Alum) is the most common adjuvant used in vaccine formulation to improve immunization by altering the epitopes’ folds. However, ...

there are little information about growth properties of low pathogenic (lp) avian influenza virus (aiv) in embryonated chicken eggs (eces) at different incubation temperatures. knowledge of this information increases the quantity and quality of antigen in vaccine production process. for this purpose, 10-5 dilution of aiv (a/chicken/iran/99/h9n2) was inoculated (intra-allantoic) into 400, 11-day...

H2N2 influenza virus caused a pandemic starting in 1957 but has not been detected in humans since 1968. Thus, most people are immunologically naive to viruses of the H2 subtype. In contrast, H2 influenza viruses are continually isolated from wild birds, and H2N3 viruses were isolated from pigs in 2006. H2 influenza viruses could cause a pandemic if re-introduced into humans. In the present stud...

BACKGROUND Simple and effective vaccine administration is particularly important for annually recommended influenza vaccination. We hypothesized that vaccine delivery to the skin using a patch containing vaccine-coated microneedles could be an attractive approach to improve influenza vaccination compliance and efficacy. METHODOLOGY/PRINCIPAL FINDINGS Solid microneedle arrays coated with inact...

Sir Influenza vaccines are safe and have the potential to prevent significant morbidity and mortality 1 . Healthcare Workers (HCWs) are at increased risk of influenza infection 2 . There are many reports of influenza outbreaks where unvaccinated HCWs have infected patients and facilitated onward spread of infection 3,4 . Vaccinating HCWs reduces influenza-related morbidity and mortality in vacc...

The purpose of this statement is to update recommendations for the routine use of seasonal influenza vaccine and antiviral medications for the prevention and treatment of influenza in children. The AAP recommends annual seasonal influenza immunization for everyone 6 months and older, including children and adolescents. Highlights for the upcoming 2016-2017 season include the following: 1. Annua...

Purpose: Surgical removal of solid primary tumors is an essential component of cancer treatment. Surgery-induced dysfunction innatural killer (NK) cells has been linked to the development ofmetastases in animalmodels andpatientswith cancer.We investigated the activationofNKcells using influenza vaccine in the perioperative period to eradicate micrometastatic disease. ExperimentalDesign:Both the...

Death by respiratory complications from influenza infections continues to be a major global health concern. Antiviral drugs are widely available for therapy and prophylaxis, but viral mutations have resulted in resistance that threatens to reduce the long-term utility of approved antivirals. Vaccination is the best method for controlling influenza, but vaccine strategies are blunted by virus an...

OBJECTIVE: Current guidelines recommend that egg-allergic patients receive an influenza vaccine skin test before the influenza vaccine. This study evaluated the safety of bypassing the skin test and administering graded doses of influenza vaccine to egg-allergic children. METHODS: We conducted a retrospective chart-review study of eggallergic patients aged 6 months to 18 years who received the ...