IL-10 is an 18-kd polypeptide that has been shown to be secreted by multiple cell types, including T and B cells, monocytes and some human tumors. However, which cell population is responsible for the elevated IL-10 levels in the serum and ascites of ovarian cancer patients, whether ovarian carcinoma cells produce IL-10, and how IL-10 influences the development and progression of ovarian carcin...

In an attempt to resolve the apparent controversy in the observed effects of gonadotrophin-releasing hormone (GnRH) analogues on the ovary, conventional binding studies were conducted with a GnRH agonist and an antagonist in various ovarian tissues to demonstrate possible GnRH receptor binding. In human luteinized granulosa cells derived from unstimulated in-vitro fertilization cycles, high aff...

Human BCCIP, a protein which interacts with BRCA2 and CDKN1A (Cip1, p21), has been implicated in many cellular processes including cell cycle regulation, DNA recombination and damage repair, telomere maintenance, embryonic development and genomic stability. BCCIP gene expression, which is an important BRCA2 cofactor in tumor suppression, has been identified in some primary cancers. Thus, we inv...

Hypomethylation of some portions of the genome and hypermethylation of others are very frequent in human cancer. The hypomethylation often involves satellite 2 (Sat2) DNA in the juxtacentromeric (centromere-adjacent) region of chromosome 1. In this study, we analyzed methylation in centromeric and juxtacentromeric satellite DNA in 115 ovarian cancers, 26 non-neoplastic ovarian specimens, and va...

Reproduction in domestic animals, as a major source of food and other products for human, has greatimportance and study of related subjects including sex differentiation and gonadogenesis during fetal life can solve many questions on normal development and various disorders of urogenital system. Since studies on sex differentiation in goat fetus are scarce, this study was performed. Twenty-five...

struma ovarii is an uncommon highly specialized ovarian teratoma that accounts for less than 5% of mature teratomas. it is composed predominantly of mature thyroid tissue. thyroid tissue is observed in 5%-15% of teratomas; however, to qualify as a struma ovarii tumor, the thyroid proportion must comprise more than 50% of the overall tissue. the combination of pseudo meigs'syndrome and elevation...

Ovarian tissue cryopreservation is the key step towards the establishment of an ovarian tissue bank or the preservation of ovarian tissue for patients scheduled for gonadotoxic cancer therapies, aiming for fertility restoration later on. Conventional cryopreservation, or slow freezing, has been the mainstay of ovarian tissue cryopreservation. Vitrification has recently emerged as a new trend fo...