Li R, Maminishkis A, Banzon T, Wan Q, Jalickee S, Chen S, Miller SS. IFN regulates retinal pigment epithelial fluid transport. Am J Physiol Cell Physiol 297: C1452–C1465, 2009. First published September 30, 2009; doi:10.1152/ajpcell.00255.2009.—The present experiments show that IFN receptors are mainly localized to the basolateral membrane of human retinal pigment epithelium (RPE). Activation o...

Recently, treatment with MEK inhibitors has been shown to be an effective treatment option for metastatic melanoma. Treatment efficacy is dependent on inhibition of MAPK-related melanoma proliferation. However, targeting of MEK can be accompanied by a time-dependent and reversible serous retinopathy of unknown origin.We analyzed the molecular mechanism by which the MEK inhibitor binimetinib may...

A hole was detected in the epithelium of a retinal pigment epithelium (RPE) detachment in two patients. Leakage through the hole led to an elevation of the overlying neurosensory retina in each case. The resulting vision was 20/70 in one eye and 20/30 in the other. The defects in the RPE occurred in a setting different from that usually seen with tears in the pigment epithelium and had a differ...

A new isolation procedure for bovine retinal pigment epithelial cells has been developed. It is based on perfusion of the whole bovine eye via the central ophthalmic artery with a cold, buffered isotonic salt solution free of divalent cations for 15 min. The perfusion both weakens the association of the pigment epithelial cells with Bruch's membrane and the adhesion between retina and pigment e...

Central serous chorioretinopathy (CSCR) is one of several retinal disorders that may cause visual loss. It characterized by detachment the neurosensory retina, often associated with focal detachments an altered pigment epithelium, mostly confined to macular area. As CSCR considered be correlated increased level testosterone, it was interest if also linked occurrence polycystic ovary syndrome (P...

In this review, we discuss about current knowledge about stem cell (SC) therapy in the treatment of retinal degeneration. Both human embryonic stem cell and induced pluripotent stem cell has been growth in culture for a long time, and started to be explored in the treatment of blinding conditions. The Food and Drug Administration, recently, has granted clinical trials using SC retinal therapy t...

The production of thermal lesions in the ocular fundus depends, among other factors, upon the spectral quality of the light incident on the cornea, and the energy-density gradient in the fundus. The latter depends, in turn, upon the concentration of pigment within the granules and the space distribution of the granules within a given stratum or layer. The distribution of pigmented granules vari...