A search for human T lymphotropic virus (HTLV) types 1 and 2 and related viruses was performed by serological and molecular means on samples obtained from 421 adult villagers from the southern Cameroon forest areas. One individual (a 56-year-old Baka Pygmy hunter) was found to be HTLV-3 infected; however, there was a low proviral load in blood cells. Complete sequence analysis of this virus (HT...

Background: The northeast of Iran is one the endemic regions human T-cell lymphotropic virus type-1 (HTLV-1). This study aimed to evaluate relationship between nasopharyngeal carcinoma and HTLV-1 infection in Iran, an area for HTLV-1. Methods: In this case-control study, paraffin-embedded tissue samples patients with definitive were evaluated presence genome by polymerase chain reaction retrosp...

Homologous env sequences from 17 human T-leukemia/lymphotropic virus type I (HTLV-I) strains from throughout the world and from 25 simian T-leukemia/lymphotropic virus type I (STLV-I) strains from 12 simian species in Asia and Africa were analyzed in a phylogenetic context as an approach to resolving the natural history of these related retroviruses. STLV-I exhibited greater overall sequence va...

OBJECTIVE To assess the prevalence of human T cell leukaemia/lymphoma virus (HTLV) infection in pregnant women in the United Kingdom. DESIGN Population study. SUBJECTS Guthrie card samples from babies born in 1997-8. Samples were linked to data on mother's age and ethnic status and parents' country of birth and then anonymised. SETTING North Thames Regional Health Authority. MAIN OUTCOM...

Human T-cell leukemia virus types 1 and 2 (HTLV-1 and HTLV-2) are delta retroviruses that share a common overall genetic organization, splicing pattern, and ability to infect and immortalize T-cells in vitro. However, HTLV-1 and HTLV-2 exhibit a clearly distinct pathogenic potential in infected patients. To find clues to the possible viral determinants of the biology of these viruses, recent st...

Synthetic peptides representing the immunodominant structural motifs of the envelope region of human T-lymphotropic virus types I (HTLV-I) (Env-1(191-214) and Env-5(242-257)) and II (HTLV-II) (Env-20(85-102 and Env-2(187-209)) were used to develop an enzyme immunoassay that could discriminate between HTLV-I and HTLV-II. Serum specimens from individuals whose infections were confirmed and typed ...

Infection with human T-lymphotropic virus type 1 (HTLV-1) can be associated with hematologic malignancy, inflammatory syndromes, or infectious complications. Herein, we bring attention to HTLV-1 infection complications as we discuss a case of disseminated cryptococcosis in a patient with HTLV-1-associated T cell lymphoma.