Owing to their present use as rocket fuels and their pharmacologic activity as central nervous system stimulants, substituted hydrazines and hydrazine derivatives have come into increasing use in recent years. The parent compound hydrazine and the methyl-substituted hydrazines are of potential hazard because of their toxicity, volatility, and explosive nature. Exposure to hydrazine vapor brings...

An efficient and green protocol for the synthesis of pyrazoles derivatives by one-pot reaction of different 1,3-dicarbonyl compounds with hydrazines/hydrazides has been developed using nano-sulfated zirconia, nano-structured ZnO, nano-g-alumina and nano-ZSM-5 zeolites, as the catalyst. The optical properties of the nano-structured catalysts and organic molecules were studied. The advantages of ...

Aldehydes and ketones are present in a number of low molecular weight molecules such as drugs, steroid hormones, reducing sugars and some metabolic intermediates such as pyruvate and α-ketoglutarate. Except for polysaccharides containing free reducing sugars, biopolymers generally lack aldehyde and ketone groups. Even those aldehydes and ketones that are found in the open-ring form of simple ca...

an efficient and green protocol for the synthesis of pyrazoles derivatives by one-pot reaction of different 1,3-dicarbonyl compounds with hydrazines/hydrazides has been developed using nano-sulfated zirconia, nano-structured zno, nano-g-alumina and nano-zsm-5 zeolites, as the catalyst. the optical properties of the nano-structured catalysts and organic molecules were studied. the advantages of ...

UNLABELLED Infections caused by bacterial species are common in immunocompromised patients and carry significant treatment costs and mortality. The emerging resistance of microorganisms to some synthetic antimicrobial agents makes it necessary to continue the research for new antimicrobial drugs. AIM To design new sulphonamide compounds with potential antibacterial and antioxidant activity. ...

Vinylidene complexes [Ru(η(5)-C5H5){[double bond, length as m-dash]C[double bond, length as m-dash]C(H)R}(PPh3)L]BPh4 (, ) [L = P(OMe)3, P(OEt)3; R = Ph, p-tolyl, Bu(t), H] react with hydrazine R1NHNH2 (R1 = H, Me, Ph) to afford nitrile derivatives [Ru(η(5)-C5H5)(N[triple bond, length as m-dash]CCH2R)(PPh3)L]BPh4 (, ) and amine R1NH2. Hydroxylamine NH2OH also reacts with vinylidenes , to yield ...

4 B r o m o x a n t h o t o x i n r e a c t s w i t h c y a n o a c e t a m i d e t o f o r m 4 b r o m o 5 , 6 d i h y d r o x a n t h o t o x i n , w h i c h o n h y d r o l y s i s w i t h c o l d h y d r o c h l o r i c a c i d l e a d s t o t h e f o r m a t i o n o f c y a n o a c e t i c a c i d d e r i v a t i v e , b u t h y d r o l y s i s b y b o i l e d h y d r o c h l o r i c a c i...

Aim: We report the synthesis and biological evaluation of a small library 15 functionalized 3-styryl-2-pyrazolines pyrazoles, derived from curcuminoids, as trypanosomicidal agents. Methods & results: The compounds were prepared via cyclization reaction between corresponding curcuminoids appropriate hydrazines. All derivatives synthesized investigated for their activities. Compounds 4a 4e sh...