We analysed the import pathway of Tim23 and of Tim17, components of the mitochondrial import machinery for matrix-targeted preproteins. Tim23 contains two independent import signals. One is located within the first 62 amino acid residues of the hydrophilic domain that, in the assembled protein, is exposed to the intermembrane space. This signal mediates translocation of Tim23 across the outer m...

In the present study, several combinations of different grades of hydroxy propyl methyl cellulose (HPMC) such as HPMC-K4M, HPMC-K15M, HPMC-K100M as hydrophilic polymers and hydrophobic polymer like ethyl cellulose(EC) are used to prepare the matrix tablets that resulted in desired and controlled drug release profile. Hydrophobic polymers provide several advantages including good stability at va...

This study focuses on the development of a drug product based on a risk assessment-based approach, within the quality by design paradigm. A prolonged release system was proposed for paliperidone (Pal) delivery, containing Kollidon® SR as an insoluble matrix agent and hydroxypropyl cellulose, hydroxypropyl methylcellulose (HPMC), or sodium carboxymethyl cellulose as a hydrophilic polymer. The ex...

Considering the structural role of type IV collagen (Col IV) in the assembly of the basement membrane (BM) and the perspective of mimicking its organization for vascular tissue engineering purposes, we studied the adsorption pattern of this protein on model hydrophilic (clean glass) and hydrophobic trichloro(octadecyl)silane (ODS) surfaces known to strongly affect the behavior of other matrix p...

the short half-life of terbutaline sulphate (tbs) requires frequent dosing for controlling chronic pulmanary disorders, such as night asthma. the purpose of the present study was to prepare sustained-release (sr) tablets of tbs to decrease the number of doses frequency and to promote the paitent compliances. it was also desirable to evaluate the capability of natural gums for preparation of sr ...

purpose: to compare the optical properties of hydrophilic and hydrophobic intraocular lenses (iols) containing uv-absorber and to determine their chemical composition. methods: optical properties of different foldable hydrophilic and hydrophobic as well as non-foldable hydrophobic polymethylmetacrylate (pmma) iols were evaluated in three powers of 15, 22 and 25 diopters. optical properties were...

polyacrylonitrile (pan) membranes with nano-porous surface and high hydrophilicity were fabricated by addition of polyoxyethylene (40) nonylphenyl ether (igepal) as an additive in the casting solution. the membranes were prepared from pan/igepal/1-methyl-2-pyrrolidone (nmp) via phase inversion induced by immersion precipitation technique. pure water was used as coagulation medium. the effects o...

BACKGROUND Following the terror attack on Utøya on 22 July 2011, the Norwegian Directorate of Health recommended a proactive model of follow-up in the municipalities. According to this model, crisis teams were to rapidly contact the survivors, and all survivors were to be assigned a fixed contact person in the municipality. The aim was to ensure early assistance and continuity of follow-up. In ...

We have investigated the topologies of Ndh (a plastid complex with NADH dehydrogenase activity) and its NDH-F subunit in thylakoids by trypsin and proteinase V8 digestion of both intact and Triton X-100-permeabilized barley thylakoids and identification of the products with antibodies against specific sequences of the NDH-A, NDH-K and NDH-F subunits. Antibody binding and protection against prot...