organophosphorus compounds are known to inhibit the esteratic site of acetylcholinesterase by phosphorylation. the phosphorylated esteratic site of acetylcholinesterase undergoes hydrolytic regeneration at a slow or negligible rate. nucleophilic agents such as hydroxytamine, hydroxamic acids, and oximes reactivate the enzyme more erapidfy than does spontaneous hydrolysis. the red cell cholinest...

N-methyl fatty hydroxamic acids (N-MFHAs) is a derivative of acid (FHA), were synthesized from ketapang seed oil (Terminalia catappa L.) with hydroxylamine enzymatically using immobilized lipase (Lipozyme TL IM). N-MFHAs that are still in mixed state triglycerides the oil. This research aims to determine optimum conditions for separation into their single components and percentage composition H...

Suberoylanilide hydroxamic acid has been shown to selectively induce tumor apoptosis in cell cultures and animal models in several types of cancers and is about as a promising new class of chemotherapeutic agents. In addition, suberoylanilide hydroxamic acid showed synergistic anticancer activity with radiation, cisplatin, and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in s...